Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2371381..2372006 Replicon chromosome
Accession NZ_CP065747
Organism Serratia plymuthica strain FDAARGOS_896

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag I6G53_RS10850 Protein ID WP_063201925.1
Coordinates 2371824..2372006 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I6G53_RS10845 Protein ID WP_063201920.1
Coordinates 2371381..2371794 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G53_RS10815 2366609..2367331 + 723 WP_004945948.1 RNA polymerase sigma factor FliA -
I6G53_RS10820 2367388..2367897 + 510 WP_197930765.1 flagella biosynthesis regulatory protein FliZ -
I6G53_RS10825 2368023..2369015 + 993 WP_063201914.1 D-cysteine desulfhydrase -
I6G53_RS10830 2369130..2369930 + 801 WP_197930767.1 cystine ABC transporter substrate-binding protein -
I6G53_RS10835 2369930..2370592 + 663 WP_006321381.1 cystine ABC transporter permease -
I6G53_RS10840 2370596..2371348 + 753 WP_062871168.1 L-cystine ABC transporter ATP-binding protein YecC -
I6G53_RS10845 2371381..2371794 - 414 WP_063201920.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6G53_RS10850 2371824..2372006 - 183 WP_063201925.1 type II toxin-antitoxin system HicA family toxin Toxin
I6G53_RS10855 2372173..2376144 - 3972 WP_197930769.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6893.14 Da        Isoelectric Point: 11.0382

>T183299 WP_063201925.1 NZ_CP065747:c2372006-2371824 [Serratia plymuthica]
VKSSELIRLLEREGWVLERIKGSHHQFKHPGSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Download         Length: 183 bp

>T183299 NZ_CP086870:1823922-1824176 [Pseudosulfitobacter pseudonitzschiae]
ATGAACAGCAAGCAGCGGAAAACACTCAAGGCGATTTTCACCGATCCGGTGTCTGGCACAATCGAATGGGTCAGGATCGA
AAGTCTCCTTGTCGCGGCTGGCGCTGAAACCATCGAAGGCAACGGCTCGCGCGTTCGCTTTGTTAAGGACGGCGTGGTTG
GATCGTTCCACCGCCCGCACCCTGACAAAGAGGCAAAGCGCTATCAGGTTAGAGACGCCCGCGCCTTCCTAACGCAGATT
GGAGTAACGCCATGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15092.85 Da        Isoelectric Point: 4.6961

>AT183299 WP_063201920.1 NZ_CP065747:c2371794-2371381 [Serratia plymuthica]
MFYPAYVHSDLDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDTLNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKVG

Download         Length: 414 bp

>AT183299 NZ_CP086870:1824173-1824502 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCACCATGACTTTCAAAGGCTATCAGGCCCGTGTGGAGTTCGATCCAGAGGACGAGATTTTCTTCGGTAGAATTGC
CGGGATAAACGATGTGGTTGGCTTCCACGGCGAAAGCGTTGCCGAGCTTAAGAGTGCCTTTCATGAAGCCGTTGATGATT
ATCTTGAAACCTGCAAGGCGGCTGGCAAGAAGCCCCAGAAGCCGTATTCTGGCAAGGTGATGTTTCGAGTCGCTCCTGAA
ACCCACAGGCGCATCGCAGTTGCAGCTGAACTTTCCGGCAAGAGCCTGAACCAGTGGGCAGAAGAAAAGCTAGAGGCTGC
TGCCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References