Detailed information of TA system TA183296

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1058237..1058906
• Replicon: chromosome
• Accession: NZ_CP065747
• Organism: Serratia plymuthica strain FDAARGOS_896

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S4YKD8
• Locus tag: I6G53_RS04710
• Protein ID: WP_006327725.1
• Coordinates: 1058484..1058906 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: I6G53_RS04705
• Protein ID: WP_197929709.1
• Coordinates: 1058237..1058503 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G53_RS04680	1053364..1054689	+	1326	WP_197929701.1	MHS family MFS transporter	-
I6G53_RS04685	1054736..1055344	-	609	WP_197929703.1	HD domain-containing protein	-
I6G53_RS04690	1055535..1056212	+	678	WP_197929705.1	hemolysin III family protein	-
I6G53_RS04695	1056375..1056872	+	498	WP_197929707.1	DUF2165 domain-containing protein	-
I6G53_RS04700	1056926..1057912	-	987	WP_006327726.1	tRNA-modifying protein YgfZ	-
I6G53_RS04705	1058237..1058503	+	267	WP_197929709.1	FAD assembly factor SdhE	Antitoxin
I6G53_RS04710	1058484..1058906	+	423	WP_006327725.1	protein YgfX	Toxin
I6G53_RS04715	1058906..1059601	+	696	WP_062868495.1	two-component system response regulator CreB	-
I6G53_RS04720	1059598..1061016	+	1419	WP_197929711.1	two-component system sensor histidine kinase CreC	-
I6G53_RS04725	1061101..1062465	+	1365	WP_063200135.1	cell envelope integrity protein CreD	-
I6G53_RS04730	1062503..1063021	-	519	WP_004952413.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16461.41 Da
• Isoelectric Point: 11.0260

>T183296 WP_006327725.1 NZ_CP065747:1058484-1058906 [Serratia plymuthica]
VAQWRCNVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLANKRLSWHGQ
EWLLAKQPWMPRYGILLTLQPTQGKKRRRLWLASDSMGKAEWRHLRQLLLHPSADDDEEP

Nucleotide

• Length: 423 bp

>T183296 NZ_CP086865:119420-119686 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10416.87 Da
• Isoelectric Point: 5.0843

>AT183296 WP_197929709.1 NZ_CP065747:1058237-1058503 [Serratia plymuthica]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDQLNDADKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT183296 NZ_CP086865:119172-119423 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Structures

Toxin

• AlphaFold DB: S4YKD8