Detailed information of TA system TA183295

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-parD/RelE(toxin)
• Location: 427443..428008
• Replicon: chromosome
• Accession: NZ_CP065747
• Organism: Serratia plymuthica strain FDAARGOS_896

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I6G53_RS01910
• Protein ID: WP_197929349.1
• Coordinates: 427443..427721 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A2X4VH61
• Locus tag: I6G53_RS01915
• Protein ID: WP_062868918.1
• Coordinates: 427739..428008 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G53_RS01890	423608..423946	-	339	WP_041416656.1	PTS lactose/cellobiose transporter subunit IIA	-
I6G53_RS01895	424303..424872	+	570	WP_062868920.1	peptidylprolyl isomerase A	-
I6G53_RS01900	425032..426717	+	1686	WP_037433755.1	sensor histidine kinase	-
I6G53_RS01905	426717..427442	+	726	WP_063200586.1	two-component system response regulator BtsR	-
I6G53_RS01910	427443..427721	-	279	WP_197929349.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6G53_RS01915	427739..428008	-	270	WP_062868918.1	hypothetical protein	Antitoxin
I6G53_RS01920	428238..429764	+	1527	WP_197929351.1	DUF853 domain-containing protein	-
I6G53_RS01925	429870..430445	+	576	WP_006328493.1	aminodeoxychorismate synthase component II	-
I6G53_RS01930	430577..431794	+	1218	WP_062868917.1	aspartate aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	418297..428008	9711

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10172.76 Da
• Isoelectric Point: 8.5141

>T183295 WP_197929349.1 NZ_CP065747:c427721-427443 [Serratia plymuthica]
VTLKRTEPAIADRMAIYDYLETKNPAAAIEIDSLISAAATRLSQNPSSGKPGQVPGTREMVIHHSYFLVYELINGLIIML
AVVHARRQWPAN

Nucleotide

• Length: 279 bp

>T183295 NZ_CP086865:119172-119423 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10352.65 Da
• Isoelectric Point: 7.0169

>AT183295 WP_062868918.1 NZ_CP065747:c428008-427739 [Serratia plymuthica]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVEAYF
AERRSKLTR

Nucleotide

• Length: 270 bp

>AT183295 NZ_CP086865:119420-119686 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Structures

Antitoxin

• AlphaFold DB: A0A2X4VH61