Detailed information of TA system TA183294

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 3254308..3255283
• Replicon: chromosome
• Accession: NZ_CP065743
• Organism: Bacillus tropicus strain FDAARGOS_897

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: I6G54_RS17950
• Protein ID: WP_033691453.1
• Coordinates: 3254308..3255045 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: D8GY54
• Locus tag: I6G54_RS17955
• Protein ID: WP_000594608.1
• Coordinates: 3255158..3255283 (+)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G54_RS17930	3249982..3250764	+	783	WP_001980020.1	class I SAM-dependent methyltransferase	-
I6G54_RS17935	3250941..3252626	-	1686	WP_001980021.1	alpha-keto acid decarboxylase family protein	-
I6G54_RS17940	3252733..3253215	+	483	WP_000191902.1	MarR family winged helix-turn-helix transcriptional regulator	-
I6G54_RS17945	3253382..3254119	+	738	WP_001980023.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
I6G54_RS17950	3254308..3255045	+	738	WP_033691453.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
I6G54_RS17955	3255158..3255283	+	126	WP_000594608.1	hypothetical protein	Antitoxin
I6G54_RS17960	3255359..3255535	+	177	WP_000852618.1	hypothetical protein	-
I6G54_RS17965	3255679..3257148	+	1470	WP_001979053.1	beta-Ala-His dipeptidase	-
I6G54_RS17970	3257740..3258198	-	459	Protein_3201	DUF5065 family protein	-
I6G54_RS17975	3258653..3259312	+	660	WP_001979058.1	CatB-related O-acetyltransferase	-
I6G54_RS17980	3259645..3260262	+	618	WP_142244172.1	SGNH/GDSL hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28433.19 Da
• Isoelectric Point: 8.2672

>T183294 WP_033691453.1 NZ_CP065743:3254308-3255045 [Bacillus tropicus]
VISNIRIGLFILVIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEVAKELNTNFRGIRSQFSTMIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T183294 NZ_CP086863:c203267-202941 [Pseudosulfitobacter pseudonitzschiae]
GTGAGGCGTGGTGAGCTGGTGACGGTCGCCCTTCAGGGCGACCACGGCAAGCCGCGTCCCGCGCTTGTGATCCAATCCGA
CCGGTTTCCGGACACCGCCACCACGACCGTCCTTCTGGTTACATCCACCTTGGTGGATGCGCCGTTGATTCGGCTGACGG
TCGAACCCTCTGCGGAGAACGGGTTGCGTATGCGATCACAGATCATGATCGACAAAGCCGTGACAGTTCGAACGGACAAG
CTGGGGAAAGCTTTCGGTCAGCTGGACGATACCGCCATGATCGAGGTGAACCGGGCACTAGCACTGTTTTTAGGAGTGGC
GGGGTAA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4878.27 Da
• Isoelectric Point: 3.9507

>AT183294 WP_000594608.1 NZ_CP065743:3255158-3255283 [Bacillus tropicus]
VIKNNDNDFFKEDNEDTTDFSLIKGDTMQQVEDLEDELKRK

Nucleotide

• Length: 126 bp

>AT183294 NZ_CP086863:c203482-203264 [Pseudosulfitobacter pseudonitzschiae]
ATGCCAACCTCTGTTTCTCACCGTGTCCAGAAGCGTCGCGATGCCTTGCGTGCCGCTGGTTTGCGCCCCGTCCAGATTTG
GGTGCCGGATACCCGCCGCCCCGGTTTCGAGGCTGAGTGCCGCCGCCAGGCTGCAATTGTAGCCAAGGCCGATCGCGCAG
ATGATACTCTGAACGATTTCCTGGATGCCTCCCTGGTCGATGTGGATGACTGGGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U6H9M7