Detailed information of TA system TA183290

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 1997261..1997783
• Replicon: chromosome
• Accession: NZ_CP065738
• Organism: Rothia kristinae strain FDAARGOS_864

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I6G21_RS08775
• Protein ID: WP_174544412.1
• Coordinates: 1997261..1997530 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A7T3F706
• Locus tag: I6G21_RS08780
• Protein ID: WP_058731839.1
• Coordinates: 1997523..1997783 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G21_RS08760	1992272..1993015	+	744	WP_099049728.1	fumarylacetoacetate hydrolase family protein	-
I6G21_RS08765	1993041..1993781	+	741	WP_165869970.1	3-keto-5-aminohexanoate cleavage protein	-
I6G21_RS08770	1993814..1997233	+	3420	WP_129357542.1	DNA polymerase III subunit alpha	-
I6G21_RS08775	1997261..1997530	-	270	WP_174544412.1	Txe/YoeB family addiction module toxin	Toxin
I6G21_RS08780	1997523..1997783	-	261	WP_058731839.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
I6G21_RS08785	1997996..1999282	+	1287	WP_129357541.1	C4-dicarboxylate ABC transporter	-
I6G21_RS08790	1999433..2001448	+	2016	WP_129357540.1	threonine--tRNA ligase	-
I6G21_RS08795	2001527..2002033	-	507	WP_058731453.1	FBP domain-containing protein	-
I6G21_RS08800	2002148..2002714	+	567	WP_058731452.1	HIT domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10859.32 Da
• Isoelectric Point: 8.9208

>T183290 WP_174544412.1 NZ_CP065738:c1997530-1997261 [Rothia kristinae]
MPDLLLTWDPDAWEDYLWWQRQDRAVLRRINTLIRDIQRHGNEGIGKPEPLRHDFAGYWSRRITAEHRLVYRLTDRQVLI
AACRYHYGQ

Nucleotide

• Length: 270 bp

>T183290 NZ_CP086861:80840-81115 [Pseudosulfitobacter pseudonitzschiae]
GTGCCTGACCTTGAATGGAAGGCATTGGCGGTCGCGGACCTGATGGCGATTGTTGACTATATCTCGGATGACAATCCCGA
TGCCGCAATTTCCCTGATGGATGACATTCAAGACAAGGTGCTTGGCCTTCTGACGCATCCCAAATCCGGCCGCCCCGGTA
GGGTGAACGACACGCGAGAGCTGGTGATCCGGCCCAACTATATCGTCGTCTATGCTGAAAACACGGCGGCGGTCACCATT
CTGCGCGTTCTTCATGCGGTGCAGATGTGGCCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9690.84 Da
• Isoelectric Point: 4.7091

>AT183290 WP_058731839.1 NZ_CP065738:c1997783-1997523 [Rothia kristinae]
VKTMTYTESRARYAEVLDGVVQDREEVVITRSGHDPVVILSLAEYESLKETAHLLRSPSNARRLLDAMQRLEAGEGERHE
LVDPDA

Nucleotide

• Length: 261 bp

>AT183290 NZ_CP086861:80554-80847 [Pseudosulfitobacter pseudonitzschiae]
ATGTCCGCTCAAACCTCGATGATTCATGTTCGTGTAGATGATCAGCTCAAGGCAAAGGCCACGGATGCCCTGTCCGGTGT
CGGCCTGACGTTGTCGGACGCCGTGCGCATCCTGCTGACCCGCGTGGCAGCAGAGGGTGGCTTGCCCGCAGGGTTGACGG
CAAATCCTGACGCCTACGATGCCTGGTTCCGCGCCAAGGTACAGGACGCATTGGCCGACGCAGCACCGGCCAAGCCGCAC
GATCAGGTGATGCGAGACGCGCGCGCCTTGATCGACGGCAAGCGCGGTGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7T3F706