Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1494208..1494699 Replicon chromosome
Accession NZ_CP065729
Organism Macrococcus caseolyticus strain FDAARGOS_868

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag I6G25_RS07885 Protein ID WP_101141631.1
Coordinates 1494208..1494558 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag I6G25_RS07890 Protein ID WP_099482357.1
Coordinates 1494559..1494699 (-) Length 47 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G25_RS07860 1489316..1491451 - 2136 WP_101141621.1 RNA-binding transcriptional accessory protein -
I6G25_RS07865 1491528..1492295 - 768 WP_101141623.1 RNA polymerase sigma factor SigB -
I6G25_RS07870 1492300..1492743 - 444 WP_101141625.1 anti-sigma B factor RsbW -
I6G25_RS07875 1492748..1493071 - 324 WP_101141627.1 anti-sigma factor antagonist -
I6G25_RS07880 1493152..1494159 - 1008 WP_101141629.1 PP2C family protein-serine/threonine phosphatase -
I6G25_RS07885 1494208..1494558 - 351 WP_101141631.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6G25_RS07890 1494559..1494699 - 141 WP_099482357.1 antitoxin MazE Antitoxin
I6G25_RS07895 1494760..1495902 - 1143 WP_101141633.1 alanine racemase -
I6G25_RS07900 1495928..1496284 - 357 WP_101141634.1 holo-ACP synthase -
I6G25_RS07905 1496226..1496756 - 531 WP_169926169.1 PH domain-containing protein -
I6G25_RS07910 1496740..1498251 - 1512 WP_101141638.1 PH domain-containing protein -
I6G25_RS07915 1498241..1498717 - 477 WP_101141640.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12726.89 Da        Isoelectric Point: 10.1643

>T183289 WP_101141631.1 NZ_CP065729:c1494558-1494208 [Macrococcus caseolyticus]
MKRGDVYLADLSPVKGSEQGGKRPVVIIQNNIGNKHSPTVIVAAITAKINKAKIPTHVEIGKTTHRLEKDSVILLEQIRT
IDKNRLIDHLTVLDKAKMKEVDTALIISLGLSIDSE

Download         Length: 351 bp

>T183289 NZ_CP086858:93732-94127 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCGTTGAGTTCGCGGACACGAATGTCGTTCTTTACCTGCTCGACGACGGCCCAAAGGCCGATCGCGCCGAGGTCAT
CCTGGGGCAGGGGCCCCGGATCAGCGTTCAGGTTCTAAACGAGTCACTGGTGAACTGCCGCCGCAAAGCTGGCCTCGGTT
GGGAGGAAGCAGCGGCCTTTCTCGAAGGCGTGCGCGCCTTGTGTCCCGTCGAAGATCTCACCGTGCAGACCCATGACGTC
GGCCGCGCTTTGGCGGAACGCTACGGCTTCTCGATCTACGACGCGATGATCGTGGCCAGCGCTTTGGTTGCGGGGTGTAC
CACGCTGTGGAGCGAGGACATGCAAGATGGCCTGCTGGTGGAAGGCCAGCTTCGCATCGTCAACCCCTTTGCATGA

Antitoxin


Download         Length: 47 a.a.        Molecular weight: 5352.91 Da        Isoelectric Point: 3.6323

>AT183289 WP_099482357.1 NZ_CP065729:c1494699-1494559 [Macrococcus caseolyticus]
MSQKLEQMLIEGYQSMAEINLSIASEHYVLECEVTDNYQTYTFDGE

Download         Length: 141 bp

>AT183289 NZ_CP086858:93515-93742 [Pseudosulfitobacter pseudonitzschiae]
ATGCAGGTCGCAAAATGGGGTAACTCGCTGGCCGTCCGTTTGCCCGCGGAGCTCGTCCGAGAGCTTGGTCTCAAGGAGGG
TGATCAGATCGACCTGGTCAAGGACGACGGTCGGGTCAGAGTCCGTCGCCTTGCTCGTGCGGATGAGGTACTTACCGGCC
TGCGCCGCTTCCGGGGCAAGTTGTCCGCAGCAGAACGTCTGAGCCGCGACGACGCACATGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References