Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 310498..310979 Replicon chromosome
Accession NZ_CP065725
Organism Oligella ureolytica strain FDAARGOS_872

Toxin (Protein)


Gene name relE Uniprot ID A0A378XBF8
Locus tag I6G29_RS01710 Protein ID WP_018574597.1
Coordinates 310719..310979 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A378XCL0
Locus tag I6G29_RS01705 Protein ID WP_018574598.1
Coordinates 310498..310719 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G29_RS01675 305685..306362 - 678 WP_018574607.1 7-cyano-7-deazaguanine synthase QueC -
I6G29_RS01680 306485..306739 - 255 WP_018574606.1 hypothetical protein -
I6G29_RS01685 306973..307248 - 276 WP_018574605.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6G29_RS01690 307232..307471 - 240 WP_018574604.1 ribbon-helix-helix protein, CopG family -
I6G29_RS01695 307777..308361 + 585 WP_018574603.1 uracil-DNA glycosylase family protein -
I6G29_RS01700 308750..309586 + 837 WP_018574601.1 prolyl oligopeptidase family serine peptidase -
I6G29_RS01705 310498..310719 + 222 WP_018574598.1 hypothetical protein Antitoxin
I6G29_RS01710 310719..310979 + 261 WP_018574597.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G29_RS01715 311011..311247 - 237 WP_083907488.1 DNA adenine methylase -
I6G29_RS01720 311280..311567 + 288 WP_115148507.1 transposase -
I6G29_RS01725 311564..312439 + 876 WP_115148508.1 IS3 family transposase -
I6G29_RS01730 312493..312618 + 126 WP_115148509.1 helix-turn-helix domain containing protein -
I6G29_RS01735 312666..313885 + 1220 WP_115148510.1 IS3 family transposase -
I6G29_RS01740 313952..314281 + 330 WP_115148511.1 hypothetical protein -
I6G29_RS01745 314209..314970 + 762 WP_115148512.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 302645..337988 35343


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-85)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10005.71 Da        Isoelectric Point: 10.5129

>T183282 WP_018574597.1 NZ_CP065725:310719-310979 [Oligella ureolytica]
MFQVIYTAKALKSLSKLDKTQARLIVAWIEKNLVNSSNPRFTGKNIKGDLADWRYRVGNYRILCHIIDQTITIEVVNIGH
RKDIYK

Download         Length: 261 bp

>T183282 NZ_CP086853:c67934-67659 [Pseudosulfitobacter pseudonitzschiae]
GTGCCTGACCTTGAATGGAAGGCATTGGCGGTCGCGGACCTGATGGCGATTGTTGACTATATCTCGGATGACAATCCCGA
TGCCGCAATTTCCCTGATGGATGACATTCAAGACAAGGTGCTTGGCCTTCTGACGCATCCCAAATCCGGCCGCCCCGGTA
GGGTGAACGACACGCGAGAGCTGGTGATCCGGCCCAACTATATCGTCGTCTATGCTGAAAACACGGCGGCGGTCACCATT
CTGCGCGTTCTTCATGCGGTGCAGATGTGGCCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8472.67 Da        Isoelectric Point: 5.1710

>AT183282 WP_018574598.1 NZ_CP065725:310498-310719 [Oligella ureolytica]
MSIISVRLNATEERLFTEYAEFHGKSLSTLLKESLAEKMEEELDAKLLVEAKEYNKKNPETYTHQQVKEKLGL

Download         Length: 222 bp

>AT183282 NZ_CP086853:c68220-67927 [Pseudosulfitobacter pseudonitzschiae]
ATGTCCGCTCAAACCTCGATGATTCATGTTCGTGTAGATGATCAGCTCAAGGCAAAGGCCACGGATGCCCTGTCCGGTGT
CGGCCTGACGTTGTCGGACGCCGTGCGCATCCTGCTGACCCGCGTGGCAGCAGAGGGTGGCTTGCCCGCAGGGTTGACGG
CAAATCCTGACGCCTACGATGCCTGGTTCCGCGCCAAGGTACAGGACGCATTGGCCGACGCAGCACCGGCCAAGCCGCAC
GATCAGGTGATGCGAGACGCGCGCGCCTTGATCGACGGCAAGCGCGGTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378XBF8

Antitoxin

Source ID Structure
AlphaFold DB A0A378XCL0

References