Detailed information of TA system TA183281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 306973..307471
• Replicon: chromosome
• Accession: NZ_CP065725
• Organism: Oligella ureolytica strain FDAARGOS_872

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: A0A378XCJ9
• Locus tag: I6G29_RS01685
• Protein ID: WP_018574605.1
• Coordinates: 306973..307248 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A378XAV7
• Locus tag: I6G29_RS01690
• Protein ID: WP_018574604.1
• Coordinates: 307232..307471 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G29_RS01655	302540..303328	+	789	Protein_283	mechanosensitive ion channel	-
I6G29_RS01660	303395..304456	+	1062	WP_018574610.1	hypothetical protein	-
I6G29_RS01665	304580..305272	-	693	WP_018574609.1	7-carboxy-7-deazaguanine synthase QueE	-
I6G29_RS01670	305273..305698	-	426	WP_018574608.1	6-carboxytetrahydropterin synthase QueD	-
I6G29_RS01675	305685..306362	-	678	WP_018574607.1	7-cyano-7-deazaguanine synthase QueC	-
I6G29_RS01680	306485..306739	-	255	WP_018574606.1	hypothetical protein	-
I6G29_RS01685	306973..307248	-	276	WP_018574605.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6G29_RS01690	307232..307471	-	240	WP_018574604.1	ribbon-helix-helix protein, CopG family	Antitoxin
I6G29_RS01695	307777..308361	+	585	WP_018574603.1	uracil-DNA glycosylase family protein	-
I6G29_RS01700	308750..309586	+	837	WP_018574601.1	prolyl oligopeptidase family serine peptidase	-
I6G29_RS01705	310498..310719	+	222	WP_018574598.1	hypothetical protein	-
I6G29_RS01710	310719..310979	+	261	WP_018574597.1	type II toxin-antitoxin system RelE/ParE family toxin	-
I6G29_RS01715	311011..311247	-	237	WP_083907488.1	DNA adenine methylase	-
I6G29_RS01720	311280..311567	+	288	WP_115148507.1	transposase	-
I6G29_RS01725	311564..312439	+	876	WP_115148508.1	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	302645..337988	35343

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10680.55 Da
• Isoelectric Point: 10.3362

>T183281 WP_018574605.1 NZ_CP065725:c307248-306973 [Oligella ureolytica]
MAWKIELTKEVAKKIRKLDKPVAKRLIQFLHERVSTLNNPRDIGEALTGSKLGEFWKYRVGDYRIICKIEDKEITILVVQ
IGHRKSIYNND

Nucleotide

• Length: 276 bp

>T183281 NZ_CP086852:97430-97825 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCGTTGAGTTCGCGGACACGAATGTCGTTCTTTACCTGCTCGACGACGGCCCAAAGGCCGATCGCGCCGAGGTCAT
CCTGGGGCAGGGGCCCCGGATCAGCGTTCAGGTTCTAAACGAGTCACTGGTGAACTGCCGCCGCAAAGCTGGCCTCGGTT
GGGAGGAAGCAGCGGCCTTTCTCGAAGGCGTGCGCGCCTTGTGTCCCGTCGAAGATCTCACCGTGCAGACCCATGACGTC
GGCCGCGCTTTGGCGGAACGCTACGGCTTCTCGATCTACGACGCGATGATCGTGGCCAGCGCTTTGGTTGCGGGGTGTAC
CACGCTGTGGAGCGAGGACATGCAAGATGGCCTGCTGGTGGAAGGCCAGCTTCGCATCGTCAACCCCTTTGCATGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9042.11 Da
• Isoelectric Point: 4.2808

>AT183281 WP_018574604.1 NZ_CP065725:c307471-307232 [Oligella ureolytica]
MNKSTNVSLRLPTELVERISHLAETTGRSRTYYMQEAIKQHIDDLEDLYLAEQALVDVRAGKSETISLETLIEEYGLED

Nucleotide

• Length: 240 bp

>AT183281 NZ_CP086852:97213-97440 [Pseudosulfitobacter pseudonitzschiae]
ATGCAGGTCGCAAAATGGGGTAACTCGCTGGCCGTCCGTTTGCCCGCGGAGCTCGTCCGAGAGCTTGGTCTCAAGGAGGG
TGATCAGATCGACCTGGTCAAGGACGACGGTCGGGTCAGAGTCCGTCGCCTTGCTCGTGCGGATGAGGTACTTACCGGCC
TGCGCCGCTTCCGGGGCAAGTTGTCCGCAGCAGAACGTCTGAGCCGCGACGACGCACATGAGCGTTGA

Structures

Toxin

• AlphaFold DB: A0A378XCJ9

Antitoxin

• AlphaFold DB: A0A378XAV7