Detailed information of TA system TA183280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2070492..2072063
• Replicon: chromosome
• Accession: NZ_CP065722
• Organism: Proteus penneri strain FDAARGOS_874

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6G31_RS09650
• Protein ID: WP_109848242.1
• Coordinates: 2070750..2072063 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0G4QFK1
• Locus tag: I6G31_RS09645
• Protein ID: WP_072064722.1
• Coordinates: 2070492..2070749 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G31_RS09620	2066461..2066604	+	144	WP_004246509.1	50S ribosomal protein L34	-
I6G31_RS09625	2066622..2066981	+	360	WP_071788569.1	ribonuclease P protein component	-
I6G31_RS09630	2066945..2067205	+	261	WP_072064717.1	membrane protein insertion efficiency factor YidD	-
I6G31_RS09635	2067208..2068848	+	1641	WP_109848243.1	membrane protein insertase YidC	-
I6G31_RS09640	2068979..2070343	+	1365	WP_006534279.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
I6G31_RS09645	2070492..2070749	+	258	WP_072064722.1	helix-turn-helix domain-containing protein	Antitoxin
I6G31_RS09650	2070750..2072063	+	1314	WP_109848242.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6G31_RS09655	2072471..2072935	+	465	WP_006534283.1	DUF1097 domain-containing protein	-
I6G31_RS09660	2073117..2074049	+	933	WP_109848241.1	metallophosphoesterase	-
I6G31_RS09665	2074073..2076037	+	1965	WP_193524914.1	hypothetical protein	-
I6G31_RS09670	2076099..2076893	-	795	WP_006534289.1	energy transducer TonB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49606.69 Da
• Isoelectric Point: 6.1362

>T183280 WP_109848242.1 NZ_CP065722:2070750-2072063 [Proteus penneri]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSSQPFDLLAAIGADTVGALRLLPSGSTPANIKKIEYHKLDDTELEKILLGYQSNTPLGMLEEYPDFRISIAGAQEKTA
LLLKDDHWCVPHNNTPTTHIIKLPIGVIEGHSYTMDLSDSVENEYLCTLIAKEFDLPVPHCSIIKTKNIKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLAPLYDIMSIYPNFGGKGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSKILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARVVRLANI

Nucleotide

• Length: 1314 bp

>T183280 NZ_CP065722:2070750-2072063 [Proteus penneri]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGGATTTTTACTAAAAAAAGCTCGGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAGCCAGGAAGTCGTCCGATCTCTCTTTCGATGCCATTACAACTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTGTTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAATTCAAGCCAACCCTTTGATCTTTTAGCGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
TAGTACACCCGCGAATATCAAAAAAATAGAATATCACAAACTCGATGACACTGAACTTGAGAAAATTCTACTAGGATATC
AATCCAATACACCACTCGGCATGCTTGAAGAATATCCTGACTTCAGAATCTCTATTGCTGGTGCGCAAGAAAAAACAGCA
TTACTTTTAAAAGATGATCATTGGTGTGTGCCACACAATAATACGCCGACTACACATATTATTAAGCTGCCTATTGGTGT
TATTGAAGGTCATTCTTATACAATGGATTTATCCGATAGTGTAGAAAATGAATATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCTGTTCCTCACTGCTCTATTATTAAAACAAAAAATATTAAAGCGCTTGCTGTAGAACGTTTTGATAGAAAA
TACTCATCAGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTCTAAATATACCTTCTGCACTAAA
ATATGAAAATGAAGGGGGCCCTGGCATTATCGATATTATGAAATATTTACTTGGCTCATCAAATGCCGATCAAGACCGTT
TTCATTTTATGAAGGCGCAAGTGCTATTTTGGCTGTTAGCGGCAACAGATGGACATGCAAAGAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTTCATCTCGCACCTCTTTATGACATTATGTCTATCTATCCCAATTTTGGAGGAAAAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCAATAGAACAAATTTTTCCTCGCC
ATTTTTACCAAACAGCCGAAGCTGTCGGTTTCGATCCTTCCTTGATGAGCAAGATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTTATACAACGCGTAAAACAGCAATTACCCGAAGATTTCCCTTCTGAGATCAGCAATACAATATTGGATGGAAT
GAAAGCACGCGTTGTTAGATTAGCTAATATTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.47 Da
• Isoelectric Point: 10.2051

>AT183280 WP_072064722.1 NZ_CP065722:2070492-2070749 [Proteus penneri]
MIIINAYQLSVHLKDVRLTKKLSQSKVAKKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT183280 NZ_CP065722:2070492-2070749 [Proteus penneri]
ATGATTATAATTAACGCCTATCAACTCAGCGTACATCTAAAAGATGTCCGATTAACAAAAAAACTATCTCAAAGTAAAGT
CGCCAAAAAAGTAGGAATTCGACAAGACACCGTGTCCAATTTTGAACTTAATCCTAATTCCACCAAACTAGAAACCTTTT
TCAAACTGCTCTCTGCACTAAATTTAGAGATGGAAATTCACCCTAAAGATGCTAAAAATAATTTAGCACACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0G4QFK1