183280

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2070492..2072063 Replicon chromosome
Accession NZ_CP065722
Organism Proteus penneri strain FDAARGOS_874

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag I6G31_RS09650 Protein ID WP_109848242.1
Coordinates 2070750..2072063 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0G4QFK1
Locus tag I6G31_RS09645 Protein ID WP_072064722.1
Coordinates 2070492..2070749 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G31_RS09620 2066461..2066604 + 144 WP_004246509.1 50S ribosomal protein L34 -
I6G31_RS09625 2066622..2066981 + 360 WP_071788569.1 ribonuclease P protein component -
I6G31_RS09630 2066945..2067205 + 261 WP_072064717.1 membrane protein insertion efficiency factor YidD -
I6G31_RS09635 2067208..2068848 + 1641 WP_109848243.1 membrane protein insertase YidC -
I6G31_RS09640 2068979..2070343 + 1365 WP_006534279.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
I6G31_RS09645 2070492..2070749 + 258 WP_072064722.1 helix-turn-helix domain-containing protein Antitoxin
I6G31_RS09650 2070750..2072063 + 1314 WP_109848242.1 type II toxin-antitoxin system HipA family toxin Toxin
I6G31_RS09655 2072471..2072935 + 465 WP_006534283.1 DUF1097 domain-containing protein -
I6G31_RS09660 2073117..2074049 + 933 WP_109848241.1 metallophosphoesterase -
I6G31_RS09665 2074073..2076037 + 1965 WP_193524914.1 hypothetical protein -
I6G31_RS09670 2076099..2076893 - 795 WP_006534289.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49606.69 Da        Isoelectric Point: 6.1362

>T183280 WP_109848242.1 NZ_CP065722:2070750-2072063 [Proteus penneri]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSSQPFDLLAAIGADTVGALRLLPSGSTPANIKKIEYHKLDDTELEKILLGYQSNTPLGMLEEYPDFRISIAGAQEKTA
LLLKDDHWCVPHNNTPTTHIIKLPIGVIEGHSYTMDLSDSVENEYLCTLIAKEFDLPVPHCSIIKTKNIKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLAPLYDIMSIYPNFGGKGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSKILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARVVRLANI

Download         Length: 1314 bp

>T183280 NZ_CP065722:2070750-2072063 [Proteus penneri]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGGATTTTTACTAAAAAAAGCTCGGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAGCCAGGAAGTCGTCCGATCTCTCTTTCGATGCCATTACAACTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTGTTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAATTCAAGCCAACCCTTTGATCTTTTAGCGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
TAGTACACCCGCGAATATCAAAAAAATAGAATATCACAAACTCGATGACACTGAACTTGAGAAAATTCTACTAGGATATC
AATCCAATACACCACTCGGCATGCTTGAAGAATATCCTGACTTCAGAATCTCTATTGCTGGTGCGCAAGAAAAAACAGCA
TTACTTTTAAAAGATGATCATTGGTGTGTGCCACACAATAATACGCCGACTACACATATTATTAAGCTGCCTATTGGTGT
TATTGAAGGTCATTCTTATACAATGGATTTATCCGATAGTGTAGAAAATGAATATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCTGTTCCTCACTGCTCTATTATTAAAACAAAAAATATTAAAGCGCTTGCTGTAGAACGTTTTGATAGAAAA
TACTCATCAGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTCTAAATATACCTTCTGCACTAAA
ATATGAAAATGAAGGGGGCCCTGGCATTATCGATATTATGAAATATTTACTTGGCTCATCAAATGCCGATCAAGACCGTT
TTCATTTTATGAAGGCGCAAGTGCTATTTTGGCTGTTAGCGGCAACAGATGGACATGCAAAGAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTTCATCTCGCACCTCTTTATGACATTATGTCTATCTATCCCAATTTTGGAGGAAAAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCAATAGAACAAATTTTTCCTCGCC
ATTTTTACCAAACAGCCGAAGCTGTCGGTTTCGATCCTTCCTTGATGAGCAAGATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTTATACAACGCGTAAAACAGCAATTACCCGAAGATTTCCCTTCTGAGATCAGCAATACAATATTGGATGGAAT
GAAAGCACGCGTTGTTAGATTAGCTAATATTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.47 Da        Isoelectric Point: 10.2051

>AT183280 WP_072064722.1 NZ_CP065722:2070492-2070749 [Proteus penneri]
MIIINAYQLSVHLKDVRLTKKLSQSKVAKKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp

>AT183280 NZ_CP065722:2070492-2070749 [Proteus penneri]
ATGATTATAATTAACGCCTATCAACTCAGCGTACATCTAAAAGATGTCCGATTAACAAAAAAACTATCTCAAAGTAAAGT
CGCCAAAAAAGTAGGAATTCGACAAGACACCGTGTCCAATTTTGAACTTAATCCTAATTCCACCAAACTAGAAACCTTTT
TCAAACTGCTCTCTGCACTAAATTTAGAGATGGAAATTCACCCTAAAGATGCTAAAAATAATTTAGCACACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0G4QFK1

References