Detailed information of TA system TA183277

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 42692..43217
• Replicon: plasmid unnamed
• Accession: NZ_CP065719
• Organism: Salmonella enterica strain FDAARGOS_878

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: I6G35_RS23800
• Protein ID: WP_001159863.1
• Coordinates: 42912..43217 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: I6G35_RS23795
• Protein ID: WP_000813641.1
• Coordinates: 42692..42910 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G35_RS23770	37979..38360	+	382	Protein_41	YgiW/YdeI family stress tolerance OB fold protein	-
I6G35_RS23775	38529..38973	+	445	Protein_42	site-specific integrase	-
I6G35_RS23780	39232..40221	-	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
I6G35_RS23785	40715..41011	-	297	WP_001687482.1	hypothetical protein	-
I6G35_RS23790	41495..42016	-	522	WP_010999942.1	hypothetical protein	-
I6G35_RS23795	42692..42910	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
I6G35_RS23800	42912..43217	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
I6G35_RS23805	43219..43509	+	291	WP_001266176.1	hypothetical protein	-
I6G35_RS23810	43506..44027	+	522	WP_000198608.1	hypothetical protein	-
I6G35_RS23815	44062..44844	+	783	WP_000082169.1	site-specific integrase	-
I6G35_RS23820	44853..45566	+	714	Protein_51	EAL domain-containing protein	-
I6G35_RS23825	45570..46079	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
I6G35_RS23830	46073..46558	+	486	WP_000905606.1	membrane protein	-
I6G35_RS23835	46835..47122	-	288	WP_071530243.1	hypothetical protein	-
I6G35_RS23840	47278..47838	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93933	93933

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T183277 WP_001159863.1 NZ_CP065719:42912-43217 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T183277 NZ_CP086848:c39491-39069 [Pseudosulfitobacter pseudonitzschiae]
ATGATCATCCTCGATACGAATGTCATCTGCGAGCTGTTGCGCCCGACCCCGGAGCCCAGGATCGAGCAATGGCTGTCCGC
TCAAGATGGTCTAAACGTCTACCTGACCTCGATATCGGAGGCGGAGCTGCGCTATGGCCTCGCGAACATGGGGAACGGCA
AGCGCCGCGCTGCGCTGATTGACGCCGTAGACCGCATCCTGCGCGAGGACCTCGCCGGGCGCATTCTGCCCTTCGACAGC
GACGCCGCGCAGGCATACGCCTCTATCGCCGCCACTCGTCGCGACGCCGGGCGACCGATTGCCCAGGCCGATTGCCAGAT
CGCATCCATTGCCCACGCCTGTGGCGCCACCGTCGCCACACGCAATACGCCCGACTTCGAGGGTTGCGAGATTGACCTGA
TCAACCCCTGGACAACCGAATGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT183277 WP_000813641.1 NZ_CP065719:42692-42910 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT183277 NZ_CP086848:c39743-39495 [Pseudosulfitobacter pseudonitzschiae]
ATGGCAAGCATTACGATCCGGAACCTTGACGATGACGTGAAGCGGCGCCTTCGCATCCGAGCGGCCGAGCATGGCCGTTC
GATGGAAGAGGAGGCGCGAGAGATCCTGCGCCAAGTCGTTGGCGACGCGAAGCCCAACCATGATCTTGCCGCGGCGATCC
GTGCGCGGGTTGGACCCTTGGGTGGCGTTGAACTTGACCTTCCGCAGCGTGAAGCCATGCATGAGCCGCCCACATTCGAC
CGAGCCTAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6