Detailed information of TA system TA183264

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RHH
• Location: 1459645..1460069
• Replicon: chromosome
• Accession: NZ_CP065713
• Organism: Sphingomonas paucimobilis strain FDAARGOS_881

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0C9M624
• Locus tag: I6G38_RS06905
• Protein ID: WP_007406919.1
• Coordinates: 1459645..1459920 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I6G38_RS06910
• Protein ID: WP_197913076.1
• Coordinates: 1459908..1460069 (-)
• Length: 54 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G38_RS06885	1455218..1455670	+	453	WP_007406920.1	large conductance mechanosensitive channel protein MscL	-
I6G38_RS06890	1455825..1456256	-	432	WP_007406932.1	Rrf2 family transcriptional regulator	-
I6G38_RS06900	1457047..1459617	-	2571	WP_007406927.1	DNA mismatch repair protein MutS	-
I6G38_RS06905	1459645..1459920	-	276	WP_007406919.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6G38_RS06910	1459908..1460069	-	162	WP_197913076.1	antitoxin	Antitoxin
I6G38_RS06915	1460220..1462478	+	2259	WP_007406925.1	NADP-dependent malic enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10372.73 Da
• Isoelectric Point: 5.5940

>T183264 WP_007406919.1 NZ_CP065713:c1459920-1459645 [Sphingomonas paucimobilis]
MAQISWSVQASLQLAAIVDYIEQFDPDAARRLGDRLIDVAESLRQFPDRGRPISHGRREMVTVRPYVLRYEHDGETVLIL
GIRHAAQLSDD

Nucleotide

• Length: 276 bp

>T183264 NZ_CP086836:26590-26916 [Pseudosulfitobacter pseudonitzschiae]
GTGAGGCGTGGTGAGCTGGTGACGGTCGCCCTTCAGGGCGACCACGGCAAGCCGCGTCCCGCGCTTGTGATCCAATCCGA
CCGGTTTCCGGACACCGCCACCACGACCGTCCTTCTGGTTACATCCACCTTGGTGGATGCGCCGTTGATTCGGCTGACGG
TCGAACCCTCTGCGGAGAACGGGTTGCGTATGCGATCACAGATCATGATCGACAAAGCCGTGACAGTTCGAACGGACAAG
CTGGGGAAAGCTTTCGGTCAGCTGGACGATACCGCCATGATCGAGGTGAACCGGGCACTAGCACTGTTTTTAGGAGTGGC
GGGGTAA

Antitoxin

Protein

• Length: 54 a.a.
• Molecular weight: 6226.04 Da
• Isoelectric Point: 5.8087

>AT183264 WP_197913076.1 NZ_CP065713:c1460069-1459908 [Sphingomonas paucimobilis]
IFEQRDEAAELAADERARADFKAGRFVSHEKMAEWLKTWGTPDRKPLPPEWLK

Nucleotide

• Length: 162 bp

>AT183264 NZ_CP086836:26375-26593 [Pseudosulfitobacter pseudonitzschiae]
ATGCCAACCTCTGTTTCTCACCGTGTCCAGAAGCGTCGCGATGCCTTGCGTGCCGCTGGTTTGCGCCCCGTCCAGATTTG
GGTGCCGGATACCCGCCGCCCCGGTTTCGAGGCTGAGTGCCGCCGCCAGGCTGCAATTGTAGCCAAGGCCGATCGCGCAG
ATGATACTCTGAACGATTTCCTGGATGCCTCCCTGGTCGATGTGGATGACTGGGAGTGA

Structures

Toxin

• AlphaFold DB: A0A0C9M624