Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 737885..738414 Replicon chromosome
Accession NZ_CP065712
Organism Staphylococcus auricularis strain FDAARGOS_882

Toxin (Protein)


Gene name mazF Uniprot ID A0A2K4C3I5
Locus tag I6G39_RS03630 Protein ID WP_059107861.1
Coordinates 738052..738414 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2K4C4W9
Locus tag I6G39_RS03625 Protein ID WP_059107862.1
Coordinates 737885..738055 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G39_RS03600 733154..733633 + 480 WP_059107867.1 PH domain-containing protein -
I6G39_RS03605 733626..735134 + 1509 WP_059107866.1 PH domain-containing protein -
I6G39_RS03610 735127..735879 + 753 WP_059107865.1 PH domain-containing protein -
I6G39_RS03615 735937..736296 + 360 WP_059107864.1 holo-ACP synthase -
I6G39_RS03620 736646..737794 + 1149 WP_059107863.1 alanine racemase -
I6G39_RS03625 737885..738055 + 171 WP_059107862.1 hypothetical protein Antitoxin
I6G39_RS03630 738052..738414 + 363 WP_059107861.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6G39_RS03635 738874..739875 + 1002 WP_059107860.1 PP2C family protein-serine/threonine phosphatase -
I6G39_RS03640 739952..740278 + 327 WP_059107859.1 anti-sigma factor antagonist -
I6G39_RS03645 740280..740759 + 480 WP_059107858.1 anti-sigma B factor RsbW -
I6G39_RS03650 740734..741504 + 771 WP_059107857.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13664.98 Da        Isoelectric Point: 10.2885

>T183263 WP_059107861.1 NZ_CP065712:738052-738414 [Staphylococcus auricularis]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIDKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMEEVNRAIFISLGLHNMKHFKS

Download         Length: 363 bp

>T183263 NZ_CP086833:115294-115560 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6441.01 Da        Isoelectric Point: 4.0115

>AT183263 WP_059107862.1 NZ_CP065712:737885-738055 [Staphylococcus auricularis]
MSNFNTTRYHNMEQILKEGYSQMADLNLSLATEAFPFECEACDCNESFLSSNHNNE

Download         Length: 171 bp

>AT183263 NZ_CP086833:115046-115297 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4C3I5

Antitoxin

Source ID Structure
AlphaFold DB A0A2K4C4W9

References