Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 786215..786726 Replicon chromosome
Accession NZ_CP065711
Organism Staphylococcus carnosus strain FDAARGOS_883

Toxin (Protein)


Gene name TsdT Uniprot ID B9DMH5
Locus tag I6G40_RS03935 Protein ID WP_015900832.1
Coordinates 786215..786421 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID B9DMH6
Locus tag I6G40_RS03940 Protein ID WP_015900833.1
Coordinates 786433..786726 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G40_RS03915 782188..783405 + 1218 WP_015900829.1 rod shape-determining protein RodA -
I6G40_RS03920 783477..783617 - 141 WP_167313208.1 hypothetical protein -
I6G40_RS03925 783693..785894 - 2202 WP_015900830.1 heavy metal translocating P-type ATPase -
I6G40_RS03930 785991..786200 - 210 WP_015900831.1 copper ion binding protein -
I6G40_RS03935 786215..786421 - 207 WP_015900832.1 cation transporter Toxin
I6G40_RS03940 786433..786726 - 294 WP_015900833.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6G40_RS03945 786891..788372 + 1482 WP_015900834.1 cardiolipin synthase -
I6G40_RS03950 788397..789044 + 648 WP_015900835.1 HD domain-containing protein -
I6G40_RS03955 789135..789647 - 513 WP_015900836.1 GNAT family N-acetyltransferase -
I6G40_RS03960 789758..790627 - 870 WP_015900837.1 membrane protein insertase YidC -
I6G40_RS03965 790716..791354 - 639 WP_015900838.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(27-65)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7833.72 Da        Isoelectric Point: 4.1353

>T183261 WP_015900832.1 NZ_CP065711:c786421-786215 [Staphylococcus carnosus]
MQNSVIKIDGMETEEEQHKLHQHLIEMTGVSAVQVDMDSNEVRISYETPVNLNNLEKEIYDAGYQILN

Download         Length: 207 bp

>T183261 NZ_CP086832:3303600-3303863 [Pseudosulfitobacter pseudonitzschiae]
ATGAAGTTCGAGTATGACCCTGACAAGAGTGCCGGGAACAAGGCCAAGCACGGCATCGACTTCGATGAAGCGCAAGCGCT
TTGGGAAGACCCGTGGCTGTTGGAGGCTCCCGCTCGAACAGATGACGAGCCGCGCTTTTTTGCAATAGGCATGATCAAGG
AACGGCATTGGTCAGCAGTTTGCACCTATCGCGGTGATATTATTCGGATCATCTCGGTGCGCCGCGCCAGAAAACAGGAG
ATTGAGCACTATGAAAGCACGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11132.76 Da        Isoelectric Point: 6.4862

>AT183261 WP_015900833.1 NZ_CP065711:c786726-786433 [Staphylococcus carnosus]
MTENDKAHHSEQIKSNLKARLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAVRLLDHHMKGCIMHKVEDGHA
EEAMEELLVTVQKLIKD

Download         Length: 294 bp

>AT183261 NZ_CP086832:3303850-3304065 [Pseudosulfitobacter pseudonitzschiae]
ATGAAAGCACGTGAGTTCGATCAAAAATTTGACACAGGTGAGAACGTCAGCGATCTTGTGGACTGGTCCAAAGCTAGGCG
GACGAATACCCAGACGAAGCGAGTCAATGTGGATTTTCCGTCGTGGGTCGTTTCTGGTTTGGATCAGAAGGCAAAGCAGC
TCGGCGTTACTCGTCAGTCGCTCATCAAACTCTGGATCGCCGAGCGGCTCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380F432

Antitoxin

Source ID Structure
AlphaFold DB A0A380F6K8

References