Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 772852..773366 Replicon chromosome
Accession NZ_CP065711
Organism Staphylococcus carnosus strain FDAARGOS_883

Toxin (Protein)


Gene name mazF Uniprot ID A0A3G4R0E2
Locus tag I6G40_RS03865 Protein ID WP_075140914.1
Coordinates 772852..773202 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID B9DMI8
Locus tag I6G40_RS03870 Protein ID WP_015900820.1
Coordinates 773199..773366 (-) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G40_RS03845 769879..770649 - 771 WP_015900815.1 RNA polymerase sigma factor SigB -
I6G40_RS03850 770624..771103 - 480 WP_015900816.1 anti-sigma B factor RsbW -
I6G40_RS03855 771105..771431 - 327 WP_015900817.1 anti-sigma factor antagonist -
I6G40_RS03860 771507..772508 - 1002 WP_015900818.1 PP2C family protein-serine/threonine phosphatase -
I6G40_RS03865 772852..773202 - 351 WP_075140914.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6G40_RS03870 773199..773366 - 168 WP_015900820.1 hypothetical protein Antitoxin
I6G40_RS03875 773447..774601 - 1155 WP_015900821.1 alanine racemase -
I6G40_RS03880 774665..775018 - 354 WP_015900822.1 holo-ACP synthase -
I6G40_RS03885 775020..775520 - 501 WP_115314364.1 PH domain-containing protein -
I6G40_RS03890 775510..776997 - 1488 WP_015900824.1 PH domain-containing protein -
I6G40_RS03895 776990..777460 - 471 WP_015900825.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13075.18 Da        Isoelectric Point: 10.0708

>T183260 WP_075140914.1 NZ_CP065711:c773202-772852 [Staphylococcus carnosus]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIQISLGLTHRN

Download         Length: 351 bp

>T183260 NZ_CP086832:1328147-1328401 [Pseudosulfitobacter pseudonitzschiae]
ATGAACAGCAAGCAGCGGAAAACACTCAAGGCGATTTTCACCGATCCGGTGTCTGGCACAATCGAATGGGTCAGGATCGA
AAGTCTCCTTGTCGCGGCTGGCGCTGAAACCATCGAAGGCAACGGCTCGCGCGTTCGCTTTGTTAAGGACGGCGTGGTTG
GATCGTTCCACCGCCCGCACCCTGACAAAGAGGCAAAGCGCTATCAGGTTAGAGACGCCCGCGCCTTCCTAACGCAGATT
GGAGTAACGCCATGA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6211.75 Da        Isoelectric Point: 3.6836

>AT183260 WP_015900820.1 NZ_CP065711:c773366-773199 [Staphylococcus carnosus]
MSTFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFSVECEACDCNESYLAFDKDE

Download         Length: 168 bp

>AT183260 NZ_CP086832:1328398-1328727 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCACCATGACTTTCAAAGGCTATCAGGCCCGTGTGGAGTTCGATCCAGAGGACGAGATTTTCTTCGGTAGAATTGC
CGGGATAAACGATGTGGTTGGCTTCCACGGCGAAAGCGTTGCCGAGCTTAAGAGTGCCTTTCATGAAGCCGTTGATGATT
ATCTTGAAACCTGCAAGGCGGCTGGCAAGAAGCCCCAGAAGCCGTATTCTGGCAAGGTGATGTTTCGAGTCGCTCCTGAA
ACCCACAGGCGCATCGCAGTTGCAGCTGAACTTTCCGGCAAGAGCCTGAACCAGTGGGCAGAAGAAAAGCTAGAGGCTGC
TGCCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G4R0E2

Antitoxin

Source ID Structure
AlphaFold DB A0A380F5Y4

References