Detailed information of TA system TA183259

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1845962..1846482
• Replicon: chromosome
• Accession: NZ_CP065710
• Organism: Staphylococcus equorum strain FDAARGOS_884

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: I6G41_RS09535
• Protein ID: WP_040762585.1
• Coordinates: 1845962..1846174 (-)
• Length: 71 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: J9GWP4
• Locus tag: I6G41_RS09540
• Protein ID: WP_002507096.1
• Coordinates: 1846189..1846482 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G41_RS09515	1841535..1842890	-	1356	WP_002507101.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
I6G41_RS09520	1842903..1843973	-	1071	WP_002507100.1	D-alanine--D-alanine ligase	-
I6G41_RS09525	1844248..1845450	+	1203	WP_002507099.1	rod shape-determining protein RodA	-
I6G41_RS09530	1845608..1845748	-	141	WP_002507098.1	hypothetical protein	-
I6G41_RS09535	1845962..1846174	-	213	WP_040762585.1	heavy-metal-associated domain-containing protein	Toxin
I6G41_RS09540	1846189..1846482	-	294	WP_002507096.1	copper-sensing transcriptional repressor CsoR	Antitoxin
I6G41_RS09545	1846626..1848110	+	1485	WP_002507095.1	cardiolipin synthase	-
I6G41_RS09550	1848238..1848888	+	651	WP_002507094.1	HD domain-containing protein	-
I6G41_RS09555	1848959..1849828	-	870	WP_197910796.1	membrane protein insertase YidC	-
I6G41_RS09560	1849916..1850554	-	639	WP_002507092.1	thiamine phosphate synthase	-
I6G41_RS09565	1850554..1851345	-	792	WP_037539469.1	hydroxyethylthiazole kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (18-67)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 8130.16 Da
• Isoelectric Point: 4.5086

>T183259 WP_040762585.1 NZ_CP065710:c1846174-1845962 [Staphylococcus equorum]
VITKVIYISGIENETQQKHIEQQLKQLHGVHQVNIEIESNNGKIFIDFETPASLNNLEKEVYDLGYEILY

Nucleotide

• Length: 213 bp

>T183259 NZ_CP086831:109488-109883 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCGTTGAGTTCGCGGACACGAATGTCGTTCTTTACCTGCTCGACGACGGCCCAAAGGCCGATCGCGCCGAGGTCAT
CCTGGGGCAGGGGCCCCGGATCAGCGTTCAGGTTCTAAACGAGTCACTGGTGAACTGCCGCCGCAAAGCTGGCCTCGGTT
GGGAGGAAGCAGCGGCCTTTCTCGAAGGCGTGCGCGCCTTGTGTCCCGTCGAAGATCTCACCGTGCAGACCCATGACGTC
GGCCGCGCTTTGGCGGAACGCTACGGCTTCTCGATCTACGACGCGATGATCGTGGCCAGCGCTTTGGTTGCGGGGTGTAC
CACGCTGTGGAGCGAGGACATGCAAGATGGCCTGCTGGTGGAAGGCCAGCTTCGCATCGTCAACCCCTTTGCATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11195.87 Da
• Isoelectric Point: 6.4791

>AT183259 WP_002507096.1 NZ_CP065710:c1846482-1846189 [Staphylococcus equorum]
MAEIQKAHHSEQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNGVATKLLDHHMKSCIMEKVEQGQQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT183259 NZ_CP086831:109271-109498 [Pseudosulfitobacter pseudonitzschiae]
ATGCAGGTCGCAAAATGGGGTAACTCGCTGGCCGTCCGTTTGCCCGCGGAGCTCGTCCGAGAGCTTGGTCTCAAGGAGGG
TGATCAGATCGACCTGGTCAAGGACGACGGTCGGGTCAGAGTCCGTCGCCTTGCTCGTGCGGATGAGGTACTTACCGGCC
TGCGCCGCTTCCGGGGCAAGTTGTCCGCAGCAGAACGTCTGAGCCGCGACGACGCACATGAGCGTTGA

Structures

Antitoxin

• AlphaFold DB: J9GWP4