Detailed information of TA system TA183258

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1834478..1835007
• Replicon: chromosome
• Accession: NZ_CP065710
• Organism: Staphylococcus equorum strain FDAARGOS_884

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: K7S376
• Locus tag: I6G41_RS09475
• Protein ID: WP_002511418.1
• Coordinates: 1834478..1834840 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: J9GY23
• Locus tag: I6G41_RS09480
• Protein ID: WP_002507108.1
• Coordinates: 1834837..1835007 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G41_RS09455	1831477..1832247	-	771	WP_002507114.1	RNA polymerase sigma factor SigB	-
I6G41_RS09460	1832222..1832704	-	483	WP_002507113.1	anti-sigma B factor RsbW	-
I6G41_RS09465	1832706..1833032	-	327	WP_002511417.1	anti-sigma factor antagonist	-
I6G41_RS09470	1833112..1834113	-	1002	WP_002507111.1	PP2C family protein-serine/threonine phosphatase	-
I6G41_RS09475	1834478..1834840	-	363	WP_002511418.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
I6G41_RS09480	1834837..1835007	-	171	WP_002507108.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
I6G41_RS09485	1835095..1836243	-	1149	WP_002507107.1	alanine racemase	-
I6G41_RS09490	1836367..1836717	-	351	WP_197910795.1	holo-ACP synthase	-
I6G41_RS09495	1836750..1837286	-	537	WP_002507105.1	PH domain-containing protein	-
I6G41_RS09500	1837279..1838784	-	1506	WP_002507104.1	PH domain-containing protein	-
I6G41_RS09505	1838777..1839256	-	480	WP_002507103.1	PH domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-112)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13432.59 Da
• Isoelectric Point: 10.2178

>T183258 WP_002511418.1 NZ_CP065710:c1834840-1834478 [Staphylococcus equorum]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSESKMKEVNVAIDISLGLHNVRNSKS

Nucleotide

• Length: 363 bp

>T183258 NZ_CP086829:231136-231402 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6305.92 Da
• Isoelectric Point: 4.0121

>AT183258 WP_002507108.1 NZ_CP065710:c1835007-1834837 [Staphylococcus equorum]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYLSSKNNNE

Nucleotide

• Length: 171 bp

>AT183258 NZ_CP086829:230888-231139 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Structures

Toxin

• AlphaFold DB: K7S376

Antitoxin

• AlphaFold DB: J9GY23