Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 870021..870627 | Replicon | chromosome |
| Accession | NZ_CP065706 | ||
| Organism | Streptococcus oralis strain FDAARGOS_886 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | I0Q0Z5 |
| Locus tag | I6G43_RS04065 | Protein ID | WP_001131504.1 |
| Coordinates | 870021..870209 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | G0I8P1 |
| Locus tag | I6G43_RS04070 | Protein ID | WP_000921490.1 |
| Coordinates | 870250..870627 (+) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6G43_RS04025 | 866270..866554 | - | 285 | WP_000101355.1 | type B 50S ribosomal protein L31 | - |
| I6G43_RS04030 | 866608..867543 | - | 936 | WP_038806239.1 | bifunctional oligoribonuclease/PAP phosphatase NrnA | - |
| I6G43_RS04035 | 867647..868090 | + | 444 | WP_001162128.1 | flavodoxin | - |
| I6G43_RS04040 | 868207..868473 | + | 267 | WP_038806238.1 | chorismate mutase | - |
| I6G43_RS04045 | 868470..868844 | + | 375 | WP_038806236.1 | fluoride efflux transporter CrcB | - |
| I6G43_RS04050 | 868838..869167 | + | 330 | WP_038806235.1 | fluoride efflux transporter CrcB | - |
| I6G43_RS04055 | 869286..869633 | + | 348 | WP_001068669.1 | 50S ribosomal protein L19 | - |
| I6G43_RS04065 | 870021..870209 | + | 189 | WP_001131504.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| I6G43_RS04070 | 870250..870627 | + | 378 | WP_000921490.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| I6G43_RS04075 | 870719..871054 | + | 336 | WP_007518694.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| I6G43_RS04080 | 871047..871334 | + | 288 | WP_038806234.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| I6G43_RS04085 | 871346..871630 | + | 285 | WP_084925709.1 | hypothetical protein | - |
| I6G43_RS04090 | 871738..872163 | - | 426 | WP_038806233.1 | toxin | - |
| I6G43_RS04095 | 872166..872501 | - | 336 | WP_038806232.1 | helix-turn-helix domain-containing protein | - |
| I6G43_RS04100 | 873494..874300 | - | 807 | WP_068981978.1 | DUF3825 domain-containing protein | - |
| I6G43_RS04105 | 874692..875105 | + | 414 | WP_038806230.1 | helix-turn-helix domain-containing protein | - |
| I6G43_RS04110 | 875112..875411 | + | 300 | WP_038806229.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7066.22 Da Isoelectric Point: 9.8674
>T183254 WP_001131504.1 NZ_CP065706:870021-870209 [Streptococcus oralis]
MPLTGKEMVKLALENGWVEVRQRGSHHHFKKEGFSYLVTIPVHGNEDLGRGLERKILKDLGL
MPLTGKEMVKLALENGWVEVRQRGSHHHFKKEGFSYLVTIPVHGNEDLGRGLERKILKDLGL
Download Length: 189 bp
>T183254 NZ_CP086826:14428-14850 [Pseudosulfitobacter pseudonitzschiae]
ATGATCATCCTCGATACGAATGTCATCTGCGAGCTGTTGCGCCCGACCCCGGAGCCCAGGATCGAGCAATGGCTGTCCGC
TCAAGATGGTCTAAACGTCTACCTGACCTCGATATCGGAGGCGGAGCTGCGCTATGGCCTCGCGAACATGGGGAACGGCA
AGCGCCGCGCTGCGCTGATTGACGCCGTAGACCGCATCCTGCGCGAGGACCTCGCCGGGCGCATTCTGCCCTTCGACAGC
GACGCCGCGCAGGCATACGCCTCTATCGCCGCCACTCGTCGCGACGCCGGGCGACCGATTGCCCAGGCCGATTGCCAGAT
CGCATCCATTGCCCACGCCTGTGGCGCCACCGTCGCCACACGCAATACGCCCGACTTCGAGGGTTGCGAGATTGACCTGA
TCAACCCCTGGACAACCGAATGA
ATGATCATCCTCGATACGAATGTCATCTGCGAGCTGTTGCGCCCGACCCCGGAGCCCAGGATCGAGCAATGGCTGTCCGC
TCAAGATGGTCTAAACGTCTACCTGACCTCGATATCGGAGGCGGAGCTGCGCTATGGCCTCGCGAACATGGGGAACGGCA
AGCGCCGCGCTGCGCTGATTGACGCCGTAGACCGCATCCTGCGCGAGGACCTCGCCGGGCGCATTCTGCCCTTCGACAGC
GACGCCGCGCAGGCATACGCCTCTATCGCCGCCACTCGTCGCGACGCCGGGCGACCGATTGCCCAGGCCGATTGCCAGAT
CGCATCCATTGCCCACGCCTGTGGCGCCACCGTCGCCACACGCAATACGCCCGACTTCGAGGGTTGCGAGATTGACCTGA
TCAACCCCTGGACAACCGAATGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 14089.23 Da Isoelectric Point: 4.7873
>AT183254 WP_000921490.1 NZ_CP065706:870250-870627 [Streptococcus oralis]
MLKTYPAIFHKEGTGYWVEFPEFGGGTEGKNIEEAMKNAREMLENVLASYIDEGMALPTPSDILKIEVSDGFVSMIQVDP
APFVRSNKAIRKNVTVPEWLVRLADREKINYSEVLAQALEKKLQV
MLKTYPAIFHKEGTGYWVEFPEFGGGTEGKNIEEAMKNAREMLENVLASYIDEGMALPTPSDILKIEVSDGFVSMIQVDP
APFVRSNKAIRKNVTVPEWLVRLADREKINYSEVLAQALEKKLQV
Download Length: 378 bp
>AT183254 NZ_CP086826:14176-14424 [Pseudosulfitobacter pseudonitzschiae]
ATGGCAAGCATTACGATCCGGAACCTTGACGATGACGTGAAGCGGCGCCTTCGCATCCGAGCGGCCGAGCATGGCCGTTC
GATGGAAGAGGAGGCGCGAGAGATCCTGCGCCAAGTCGTTGGCGACGCGAAGCCCAACCATGATCTTGCCGCGGCGATCC
GTGCGCGGGTTGGACCCTTGGGTGGCGTTGAACTTGACCTTCCGCAGCGTGAAGCCATGCATGAGCCGCCCACATTCGAC
CGAGCCTAA
ATGGCAAGCATTACGATCCGGAACCTTGACGATGACGTGAAGCGGCGCCTTCGCATCCGAGCGGCCGAGCATGGCCGTTC
GATGGAAGAGGAGGCGCGAGAGATCCTGCGCCAAGTCGTTGGCGACGCGAAGCCCAACCATGATCTTGCCGCGGCGATCC
GTGCGCGGGTTGGACCCTTGGGTGGCGTTGAACTTGACCTTCCGCAGCGTGAAGCCATGCATGAGCCGCCCACATTCGAC
CGAGCCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X1GE33 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0I8P1 |