Detailed information of TA system TA183252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4063615..4064201
• Replicon: chromosome
• Accession: NZ_CP065700
• Organism: Atlantibacter hermannii strain FDAARGOS_888

Toxin (Protein)

• Gene name: doc
• Uniprot ID: H5V3H7
• Locus tag: I6G45_RS19045
• Protein ID: WP_002436531.1
• Coordinates: 4063615..4063983 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: H5V3H8
• Locus tag: I6G45_RS19050
• Protein ID: WP_002436532.1
• Coordinates: 4063980..4064201 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G45_RS19025	4059257..4060324	-	1068	WP_002436522.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-
I6G45_RS19030	4060334..4061179	-	846	WP_002436525.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
I6G45_RS19035	4061176..4062063	-	888	WP_002436527.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
I6G45_RS19040	4062124..4063437	-	1314	WP_002436529.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
I6G45_RS19045	4063615..4063983	-	369	WP_002436531.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
I6G45_RS19050	4063980..4064201	-	222	WP_002436532.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I6G45_RS19055	4064288..4065001	-	714	WP_040459930.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
I6G45_RS19060	4065003..4065770	-	768	WP_002436534.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
I6G45_RS19065	4065767..4067044	-	1278	WP_002436535.1	high-affinity branched-chain amino acid ABC transporter permease LivM	-
I6G45_RS19070	4067041..4067967	-	927	WP_002436536.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
I6G45_RS19075	4068003..4069118	-	1116	WP_040459974.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4058520..4076044	17524

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (30-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-53)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13599.99 Da
• Isoelectric Point: 9.9883

>T183252 WP_002436531.1 NZ_CP065700:c4063983-4063615 [Atlantibacter hermannii]
MTIQFISAEEIIRFHDRLLAVTPGVPGMVDPGRAEALLYRVLNKYKYEGVNDLWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGITLPANPAFVELTVAAAAGQLSLEEIARQLRK

Nucleotide

• Length: 369 bp

>T183252 NZ_CP086824:c545656-545393 [Pseudosulfitobacter pseudonitzschiae]
ATGAAGTTCGAGTATGACCCTGACAAGAGTGCCGGGAACAAGGCCAAGCACGGCATCGACTTCGATGAAGCGCAAGCGCT
TTGGGAAGACCCGTGGCTGTTGGAGGCTCCCGCTCGAACAGATGACGAGCCGCGCTTTTTTGCAATAGGCATGATCAAGG
AACGGCATTGGTCAGCAGTTTGCACCTATCGCGGTGATATTATTCGGATCATCTCGGTGCGCCGCGCCAGAAAACAGGAG
ATTGAGCACTATGAAAGCACGTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8091.20 Da
• Isoelectric Point: 5.6512

>AT183252 WP_002436532.1 NZ_CP065700:c4064201-4063980 [Atlantibacter hermannii]
MQTMNYSEARQNLAAALETAALGTPVTITRRGHKPAVIISAEEFERYQQAKMDAEFAAIMAIHGNEIRELADK

Nucleotide

• Length: 222 bp

>AT183252 NZ_CP086824:c545406-545191 [Pseudosulfitobacter pseudonitzschiae]
ATGAAAGCACGTGAGTTCGATCAAAAATTTGACACAGGTGAGAACGTCAGCGATCTTGTGGACTGGTCCAAAGCTAGGCG
GACGAATACCCAGACGAAGCGAGTCAATGTGGATTTTCCGTCGTGGGTCGTTTCTGGTTTGGATCAGAAGGCAAAGCAGC
TCGGCGTTACTCGTCAGTCGCTCATCAAACTCTGGATCGCCGAGCGGCTCCAATGA

Structures

Toxin

• AlphaFold DB: H5V3H7

Antitoxin

• AlphaFold DB: H5V3H8