Detailed information of TA system TA183251

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 3404800..3405452
• Replicon: chromosome
• Accession: NZ_CP065700
• Organism: Atlantibacter hermannii strain FDAARGOS_888

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: H5V7Q7
• Locus tag: I6G45_RS15910
• Protein ID: WP_002438660.1
• Coordinates: 3405138..3405452 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: H5V7Q6
• Locus tag: I6G45_RS15905
• Protein ID: WP_002438659.1
• Coordinates: 3404800..3405117 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G45_RS15865	3400082..3400366	-	285	WP_002438650.1	IS3 family transposase	-
I6G45_RS15870	3400575..3401438	+	864	WP_002438652.1	GTPase family protein	-
I6G45_RS15875	3401531..3402352	+	822	WP_002438653.1	DUF945 domain-containing protein	-
I6G45_RS15880	3402569..3403102	+	534	Protein_3090	DeoR family transcriptional regulator	-
I6G45_RS15885	3403265..3403492	+	228	WP_081479374.1	DUF905 domain-containing protein	-
I6G45_RS15890	3403601..3404059	+	459	WP_002438656.1	antirestriction protein	-
I6G45_RS15895	3404075..3404551	+	477	WP_002438657.1	RadC family protein	-
I6G45_RS15900	3404560..3404781	+	222	WP_000691995.1	DUF987 domain-containing protein	-
I6G45_RS15905	3404800..3405117	+	318	WP_002438659.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
I6G45_RS15910	3405138..3405452	+	315	WP_002438660.1	TA system toxin CbtA family protein	Toxin
I6G45_RS15915	3405592..3405897	+	306	WP_002438661.1	hypothetical protein	-
I6G45_RS15920	3405924..3407003	-	1080	Protein_3098	IS3 family transposase	-
I6G45_RS15925	3407142..3408671	+	1530	WP_002438597.1	Eco57I restriction-modification methylase domain-containing protein	-
I6G45_RS15930	3408721..3409722	-	1002	WP_002438595.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3356245..3408671	52426
	-	flank	IS/Tn	-	-	3406118..3406909	791

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-104)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11636.46 Da
• Isoelectric Point: 6.4533

>T183251 WP_002438660.1 NZ_CP065700:3405138-3405452 [Atlantibacter hermannii]
MKTLPATTPQAAKLCLPPVAVWQMLLARLLEQHYGLTLNDTSFSDETVIQEHIDAGITLADAVNFLVDKYELVRIDRRGL
SWQAQSSYLRAVDILRARQATGLL

Nucleotide

• Length: 315 bp

>T183251 NZ_CP086823:26279-26554 [Pseudosulfitobacter pseudonitzschiae]
GTGCCTGACCTTGAATGGAAGGCATTGGCGGTCGCGGACCTGATGGCGATTGTTGACTATATCTCGGATGACAATCCCGA
TGCCGCAATTTCCCTGATGGATGACATTCAAGACAAGGTGCTTGGCCTTCTGACGCATCCCAAATCCGGCCGCCCCGGTA
GGGTGAACGACACGCGAGAGCTGGTGATCCGGCCCAACTATATCGTCGTCTATGCTGAAAACACGGCGGCGGTCACCATT
CTGCGCGTTCTTCATGCGGTGCAGATGTGGCCCTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11953.51 Da
• Isoelectric Point: 6.6244

>AT183251 WP_002438659.1 NZ_CP065700:3404800-3405117 [Atlantibacter hermannii]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDAECQKLDETFPHFISQIESMLTTYELNPRHAHCVILYH
NGFTCEADTLGSCGYVYVAVYPTQR

Nucleotide

• Length: 318 bp

>AT183251 NZ_CP086823:25993-26286 [Pseudosulfitobacter pseudonitzschiae]
ATGTCCGCTCAAACCTCGATGATTCATGTTCGTGTAGATGATCAGCTCAAGGCAAAGGCCACGGATGCCCTGTCCGGTGT
CGGCCTGACGTTGTCGGACGCCGTGCGCATCCTGCTGACCCGCGTGGCAGCAGAGGGTGGCTTGCCCGCAGGGTTGACGG
CAAATCCTGACGCCTACGATGCCTGGTTCCGCGCCAAGGTACAGGACGCATTGGCCGACGCAGCACCGGCCAAGCCGCAC
GATCAGGTGATGCGAGACGCGCGCGCCTTGATCGACGGCAAGCGCGGTGCCTGA

Structures

Toxin

• AlphaFold DB: H5V7Q7

Antitoxin

• AlphaFold DB: H5V7Q6