Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3188708..3189329 Replicon chromosome
Accession NZ_CP065700
Organism Atlantibacter hermannii strain FDAARGOS_888

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag I6G45_RS14925 Protein ID WP_001291435.1
Coordinates 3189111..3189329 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H5UYE1
Locus tag I6G45_RS14920 Protein ID WP_002463720.1
Coordinates 3188708..3189082 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G45_RS14910 3183868..3185064 + 1197 WP_002463714.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I6G45_RS14915 3185087..3188236 + 3150 WP_002463716.1 multidrug efflux RND transporter permease subunit -
I6G45_RS14920 3188708..3189082 + 375 WP_002463720.1 Hha toxicity modulator TomB Antitoxin
I6G45_RS14925 3189111..3189329 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
I6G45_RS14930 3189791..3190258 + 468 WP_002463722.1 YlaC family protein -
I6G45_RS14935 3190294..3190434 - 141 WP_061708247.1 type B 50S ribosomal protein L36 -
I6G45_RS14940 3190437..3190697 - 261 WP_002463724.1 type B 50S ribosomal protein L31 -
I6G45_RS14945 3190952..3192502 + 1551 WP_040459529.1 EAL domain-containing protein -
I6G45_RS14950 3192641..3192859 - 219 WP_002463728.1 hypothetical protein -
I6G45_RS14955 3192856..3193107 - 252 WP_002463729.1 hypothetical protein -
I6G45_RS14960 3193480..3193860 - 381 WP_040459530.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T183250 WP_001291435.1 NZ_CP065700:3189111-3189329 [Atlantibacter hermannii]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T183250 NZ_CP086820:c56220-55969 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14380.16 Da        Isoelectric Point: 5.1259

>AT183250 WP_002463720.1 NZ_CP065700:3188708-3189082 [Atlantibacter hermannii]
MDEYSPKRHDIAQLKFLCENLYHDCLLTLGDSNHGWVNDPTSAINLQLNELIEHIASFALNYKIKHDEDNALIEHVDEYL
DDTFMLFSNYGISAQDLQKWRKSGNRLFRCFVNVSKANPVSLSF

Download         Length: 375 bp

>AT183250 NZ_CP086820:c55972-55706 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB H5UYE1

References