Detailed information of TA system TA183238

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4900425..4901094
• Replicon: chromosome
• Accession: NZ_CP065699
• Organism: Serratia plymuthica strain FDAARGOS_889

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S4YKD8
• Locus tag: I6G46_RS22915
• Protein ID: WP_006327725.1
• Coordinates: 4900672..4901094 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S4YS10
• Locus tag: I6G46_RS22910
• Protein ID: WP_004952428.1
• Coordinates: 4900425..4900691 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G46_RS22885	4895549..4896874	+	1326	WP_197912341.1	MHS family MFS transporter	-
I6G46_RS22890	4896924..4897532	-	609	WP_013814383.1	HD domain-containing protein	-
I6G46_RS22895	4897723..4898400	+	678	WP_062868500.1	hemolysin III family protein	-
I6G46_RS22900	4898563..4899060	+	498	WP_006327727.1	DUF2165 domain-containing protein	-
I6G46_RS22905	4899114..4900100	-	987	WP_006327726.1	tRNA-modifying protein YgfZ	-
I6G46_RS22910	4900425..4900691	+	267	WP_004952428.1	FAD assembly factor SdhE	Antitoxin
I6G46_RS22915	4900672..4901094	+	423	WP_006327725.1	protein YgfX	Toxin
I6G46_RS22920	4901094..4901789	+	696	WP_004952420.1	two-component system response regulator CreB	-
I6G46_RS22925	4901786..4903204	+	1419	WP_006327719.1	two-component system sensor histidine kinase CreC	-
I6G46_RS22930	4903289..4904653	+	1365	WP_004952415.1	cell envelope integrity protein CreD	-
I6G46_RS22935	4904691..4905209	-	519	WP_004952413.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16461.41 Da
• Isoelectric Point: 11.0260

>T183238 WP_006327725.1 NZ_CP065699:4900672-4901094 [Serratia plymuthica]
VAQWRCNVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLANKRLSWHGQ
EWLLAKQPWMPRYGILLTLQPTQGKKRRRLWLASDSMGKAEWRHLRQLLLHPSADDDEEP

Nucleotide

• Length: 423 bp

>T183238 NZ_CP086809:c156112-155861 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10446.90 Da
• Isoelectric Point: 5.0843

>AT183238 WP_004952428.1 NZ_CP065699:4900425-4900691 [Serratia plymuthica]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDQLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT183238 NZ_CP086809:c155864-155598 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Structures

Toxin

• AlphaFold DB: S4YKD8

Antitoxin

• AlphaFold DB: S4YS10