183237

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE(toxin)
Location 4205571..4206142 Replicon chromosome
Accession NZ_CP065699
Organism Serratia plymuthica strain FDAARGOS_889

Toxin (Protein)


Gene name relE Uniprot ID S4YNR1
Locus tag I6G46_RS19790 Protein ID WP_020439916.1
Coordinates 4205571..4205849 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID S4YTP6
Locus tag I6G46_RS19795 Protein ID WP_004951261.1
Coordinates 4205873..4206142 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G46_RS19770 4201737..4202075 - 339 WP_006328508.1 PTS lactose/cellobiose transporter subunit IIA -
I6G46_RS19775 4202431..4203000 + 570 WP_006328507.1 peptidylprolyl isomerase A -
I6G46_RS19780 4203160..4204845 + 1686 WP_037433755.1 sensor histidine kinase -
I6G46_RS19785 4204845..4205570 + 726 WP_004951264.1 two-component system response regulator BtsR -
I6G46_RS19790 4205571..4205849 - 279 WP_020439916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G46_RS19795 4205873..4206142 - 270 WP_004951261.1 hypothetical protein Antitoxin
I6G46_RS19800 4206372..4207898 + 1527 WP_006328494.1 DUF853 family protein -
I6G46_RS19805 4208004..4208579 + 576 WP_006328493.1 aminodeoxychorismate synthase component II -
I6G46_RS19810 4208711..4209928 + 1218 WP_062868917.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10242.84 Da        Isoelectric Point: 8.5141

>T183237 WP_020439916.1 NZ_CP065699:c4205849-4205571 [Serratia plymuthica]
VTLKWTEPAIADRIAIYDYLETKNPAAAIEIDSLISATATRLSQNPSSGKPGRVPGTREMVIHHSYFLVYELINGLIIML
AVVHARRQWPAN

Download         Length: 279 bp

>T183237 NZ_CP086809:c155864-155598 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10364.70 Da        Isoelectric Point: 7.0169

>AT183237 WP_004951261.1 NZ_CP065699:c4206142-4205873 [Serratia plymuthica]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVEAYF
AERRSKLIR

Download         Length: 270 bp

>AT183237 NZ_CP086809:c156112-155861 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4YNR1

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KXK3

References