Detailed information of TA system TA183236

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3312727..3314350
• Replicon: chromosome
• Accession: NZ_CP065699
• Organism: Serratia plymuthica strain FDAARGOS_889

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6G46_RS15695
• Protein ID: WP_197912198.1
• Coordinates: 3312727..3314049 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: S4YPP9
• Locus tag: I6G46_RS15700
• Protein ID: WP_020438366.1
• Coordinates: 3314054..3314350 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G46_RS15680	3309482..3310639	-	1158	WP_197912197.1	hypothetical protein	-
I6G46_RS15685	3310931..3311464	-	534	WP_197912975.1	hypothetical protein	-
I6G46_RS15690	3311583..3312545	-	963	WP_062869436.1	toll/interleukin-1 receptor domain-containing protein	-
I6G46_RS15695	3312727..3314049	-	1323	WP_197912198.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6G46_RS15700	3314054..3314350	-	297	WP_020438366.1	helix-turn-helix transcriptional regulator	Antitoxin
I6G46_RS15705	3314558..3315193	-	636	WP_197912199.1	carbonic anhydrase	-
I6G46_RS15710	3316127..3316687	+	561	WP_006323369.1	hypothetical protein	-
I6G46_RS15715	3317000..3317322	-	323	Protein_3079	DNA-binding transcriptional regulator	-
I6G46_RS15720	3317306..3317443	-	138	WP_100220743.1	type II toxin-antitoxin system RelE/ParE family toxin	-
I6G46_RS15730	3318153..3318431	+	279	WP_144080223.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3288437..3314350	25913

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-68)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 50095.04 Da
• Isoelectric Point: 6.5612

>T183236 WP_197912198.1 NZ_CP065699:c3314049-3312727 [Serratia plymuthica]
MRRSQQRLAIWMNGIPVGYWEKRKGEDRLEYLPDWIADSQGRPLSLSLPFTPGNQPYRGSVVRDYFDNLLPDSGGIRRRL
AMRYHAESLDPFDLLTELGRDCVGAIQLLDTDEQPSHIFSIRQRPLSEAQIAERLRNTATMLPGRQDQDDDLRLSIAGAQ
EKTALLWHDDQWCLPEGNTPTTHIFKLALGLVGNMRADMSTSTENEWLCSLILEHYGVPVARTHIAQFEDQKALIVERFD
RKLSSDRQWWIRLPQEDMCQALGVSPLKKYQSDGGPGITDIMEVLSRSDQAETDRRHFFKAQIIFWLLAATDGHAKNCSL
AHLPQNRYHLTPLYDVLSAWPLIGPGNSQIAWQKCKLAMAVRGSSNYYHISQIRRRHWIKHGEITGLGQQEVESIIEELL
AVTPGVIDRVAELLPEQFPPELAACIFDGIRQQCARLAGK

Nucleotide

• Length: 1323 bp

>T183236 NZ_CP086808:c2065258-2065004 [Pseudosulfitobacter pseudonitzschiae]
ATGAACAGCAAGCAGCGGAAAACACTCAAGGCGATTTTCACCGATCCGGTGTCTGGCACAATCGAATGGGTCAGGATCGA
AAGTCTCCTTGTCGCGGCTGGCGCTGAAACCATCGAAGGCAACGGCTCGCGCGTTCGCTTTGTTAAGGACGGCGTGGTTG
GATCGTTCCACCGCCCGCACCCTGACAAAGAGGCAAAGCGCTATCAGGTTAGAGACGCCCGCGCCTTCCTAACGCAGATT
GGAGTAACGCCATGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10965.46 Da
• Isoelectric Point: 8.0099

>AT183236 WP_020438366.1 NZ_CP065699:c3314350-3314054 [Serratia plymuthica]
MNTVYPLKTLSQLRPLLVGFRKAKGLTQKDVSERLGVTQQTYARLESNPASASLERLFRVFNVLGIEVVLSSELTSPGCE
TEDTSTTHIDSPARREQW

Nucleotide

• Length: 297 bp

>AT183236 NZ_CP086808:c2065007-2064678 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCACCATGACTTTCAAAGGCTATCAGGCCCGTGTGGAGTTCGATCCAGAGGACGAGATTTTCTTCGGTAGAATTGC
CGGGATAAACGATGTGGTTGGCTTCCACGGCGAAAGCGTTGCCGAGCTTAAGAGTGCCTTTCATGAAGCCGTTGATGATT
ATCTTGAAACCTGCAAGGCGGCTGGCAAGAAGCCCCAGAAGCCGTATTCTGGCAAGGTGATGTTTCGAGTCGCTCCTGAA
ACCCACAGGCGCATCGCAGTTGCAGCTGAACTTTCCGGCAAGAGCCTGAACCAGTGGGCAGAAGAAAAGCTAGAGGCTGC
TGCCCACTAA

Structures

Antitoxin

• AlphaFold DB: S4YPP9