183233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2701349..2701971 Replicon chromosome
Accession NZ_CP065699
Organism Serratia plymuthica strain FDAARGOS_889

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag I6G46_RS12835 Protein ID WP_006322256.1
Coordinates 2701768..2701971 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag I6G46_RS12830 Protein ID WP_004949348.1
Coordinates 2701349..2701717 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G46_RS12800 2697391..2697645 + 255 WP_004949355.1 type B 50S ribosomal protein L31 -
I6G46_RS12805 2697658..2697798 + 141 WP_004949353.1 type B 50S ribosomal protein L36 -
I6G46_RS12810 2697913..2698791 - 879 WP_006323980.1 metal ABC transporter substrate-binding protein -
I6G46_RS12815 2698817..2699674 - 858 WP_004949351.1 metal ABC transporter permease -
I6G46_RS12820 2699671..2700384 - 714 WP_006323974.1 ABC transporter ATP-binding protein -
I6G46_RS12825 2700836..2701189 + 354 WP_004949349.1 hypothetical protein -
I6G46_RS12830 2701349..2701717 + 369 WP_004949348.1 Hha toxicity modulator TomB Antitoxin
I6G46_RS12835 2701768..2701971 + 204 WP_006322256.1 hemolysin expression modulator Hha Toxin
I6G46_RS12840 2702211..2702747 - 537 WP_006323971.1 cytochrome b/b6 domain-containing protein -
I6G46_RS12845 2702808..2704229 - 1422 WP_020438550.1 N-acetylglucosamine-binding protein GbpA -
I6G46_RS12850 2704509..2704883 + 375 WP_006323969.1 type II secretion system pilot lipoprotein GspS -
I6G46_RS12855 2704880..2705710 - 831 WP_006323964.1 A24 family peptidase -
I6G46_RS12860 2705743..2706204 - 462 WP_006323963.1 type II secretion system protein M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T183233 WP_006322256.1 NZ_CP065699:2701768-2701971 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T183233 NZ_CP086803:c14136-13741 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCGTTGAGTTCGCGGACACGAATGTCGTTCTTTACCTGCTCGACGACGGCCCAAAGGCCGATCGCGCCGAGGTCAT
CCTGGGGCAGGGGCCCCGGATCAGCGTTCAGGTTCTAAACGAGTCACTGGTGAACTGCCGCCGCAAAGCTGGCCTCGGTT
GGGAGGAAGCAGCGGCCTTTCTCGAAGGCGTGCGCGCCTTGTGTCCCGTCGAAGATCTCACCGTGCAGACCCATGACGTC
GGCCGCGCTTTGGCGGAACGCTACGGCTTCTCGATCTACGACGCGATGATCGTGGCCAGCGCTTTGGTTGCGGGGTGTAC
CACGCTGTGGAGCGAGGACATGCAAGATGGCCTGCTGGTGGAAGGCCAGCTTCGCATCGTCAACCCCTTTGCATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT183233 WP_004949348.1 NZ_CP065699:2701349-2701717 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp

>AT183233 NZ_CP086803:c14353-14126 [Pseudosulfitobacter pseudonitzschiae]
ATGCAGGTCGCAAAATGGGGTAACTCGCTGGCCGTCCGTTTGCCCGCGGAGCTCGTCCGAGAGCTTGGTCTCAAGGAGGG
TGATCAGATCGACCTGGTCAAGGACGACGGTCGGGTCAGAGTCCGTCGCCTTGCTCGTGCGGATGAGGTACTTACCGGCC
TGCGCCGCTTCCGGGGCAAGTTGTCCGCAGCAGAACGTCTGAGCCGCGACGACGCACATGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KM53

Antitoxin

Source ID Structure
AlphaFold DB S4YKH5

References