Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2181026..2181579 Replicon chromosome
Accession NZ_CP065699
Organism Serratia plymuthica strain FDAARGOS_889

Toxin (Protein)


Gene name ccdB Uniprot ID S4YH80
Locus tag I6G46_RS10245 Protein ID WP_020438747.1
Coordinates 2181026..2181340 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S4YG56
Locus tag I6G46_RS10250 Protein ID WP_020438746.1
Coordinates 2181343..2181579 (-) Length 79 a.a.

Genomic Context

I6G46_RS10230I6G46_RS10235I6G46_RS10240I6G46_RS10225I6G46_RS10245I6G46_RS10250I6G46_RS10255I6G46_RS10260I6G46_RS10265
Location: 2178059..2178976 (918 bp)
Type: Others
Protein ID: WP_004942342.1
Location: 2179005..2180132 (1128 bp)
Type: Others
Protein ID: WP_004942340.1
Location: 2180147..2180992 (846 bp)
Type: Others
Protein ID: WP_006324390.1
Location: 2176794..2177951 (1158 bp)
Type: Others
Protein ID: WP_006324392.1
Location: 2181026..2181340 (315 bp)
Type: Toxin
Protein ID: WP_020438747.1
Location: 2181343..2181579 (237 bp)
Type: Antitoxin
Protein ID: WP_020438746.1
Location: 2181724..2182632 (909 bp)
Type: Others
Protein ID: WP_004942335.1
Location: 2182642..2183562 (921 bp)
Type: Others
Protein ID: WP_006324386.1
Location: 2183615..2185153 (1539 bp)
Type: Others
Protein ID: WP_006324385.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6G46_RS102252176794..2177951-1158WP_006324392.1YbfB/YjiJ family MFS transporter-
I6G46_RS102302178059..2178976+918WP_004942342.1LysR family transcriptional regulator-
I6G46_RS102352179005..2180132+1128WP_004942340.1S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase-
I6G46_RS102402180147..2180992+846WP_006324390.1S-formylglutathione hydrolase-
I6G46_RS102452181026..2181340-315WP_020438747.1CcdB family proteinToxin
I6G46_RS102502181343..2181579-237WP_020438746.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
I6G46_RS102552181724..2182632-909WP_004942335.1glutathione ABC transporter permease GsiD-
I6G46_RS102602182642..2183562-921WP_006324386.1glutathione ABC transporter permease GsiC-
I6G46_RS102652183615..2185153-1539WP_006324385.1glutathione ABC transporter substrate-binding protein GsiB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11685.58 Da        Isoelectric Point: 5.8036

>T183232 WP_020438747.1 NZ_CP065699:c2181340-2181026 [Serratia plymuthica]
MQFTVYANTGKSAVYPLLLDVTSDIIGQLNRRVVIPLLPIEKYPASTRPERLNPLVRLVDDNEYAVMTHEMASIPVRILG
AEFCDASQYRTKVKAAIDFLFDGI

Download         Length: 315 bp

>T183232 NZ_CP086802:143014-143436 [Pseudosulfitobacter pseudonitzschiae]
ATGATCATCCTCGATACGAATGTCATCTGCGAGCTGTTGCGCCCGACCCCGGAGCCCAGGATCGAGCAATGGCTGTCCGC
TCAAGATGGTCTAAACGTCTACCTGACCTCGATATCGGAGGCGGAGCTGCGCTATGGCCTCGCGAACATGGGGAACGGCA
AGCGCCGCGCTGCGCTGATTGACGCCGTAGACCGCATCCTGCGCGAGGACCTCGCCGGGCGCATTCTGCCCTTCGACAGC
GACGCCGCGCAGGCATACGCCTCTATCGCCGCCACTCGTCGCGACGCCGGGCGACCGATTGCCCAGGCCGATTGCCAGAT
CGCATCCATTGCCCACGCCTGTGGCGCCACCGTCGCCACACGCAATACGCCCGACTTCGAGGGTTGCGAGATTGACCTGA
TCAACCCCTGGACAACCGAATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9078.16 Da        Isoelectric Point: 6.7184

>AT183232 WP_020438746.1 NZ_CP065699:c2181579-2181343 [Serratia plymuthica]
MPVKQRTTQSVTMAVERSLLSRAREAGINLSATLNAALDAELRQHEMRKWKEENREAIDALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT183232 NZ_CP086802:142762-143010 [Pseudosulfitobacter pseudonitzschiae]
ATGGCAAGCATTACGATCCGGAACCTTGACGATGACGTGAAGCGGCGCCTTCGCATCCGAGCGGCCGAGCATGGCCGTTC
GATGGAAGAGGAGGCGCGAGAGATCCTGCGCCAAGTCGTTGGCGACGCGAAGCCCAACCATGATCTTGCCGCGGCGATCC
GTGCGCGGGTTGGACCCTTGGGTGGCGTTGAACTTGACCTTCCGCAGCGTGAAGCCATGCATGAGCCGCCCACATTCGAC
CGAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBS4YH80

Antitoxin

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Source
ID
Structure
AlphaFold DBS4YG56

References