183223

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 633529..634154 Replicon chromosome
Accession NZ_CP065699
Organism Serratia plymuthica strain FDAARGOS_889

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag I6G46_RS02965 Protein ID WP_073999815.1
Coordinates 633972..634154 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I6G46_RS02960 Protein ID WP_197912568.1
Coordinates 633529..633942 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G46_RS02930 628758..629480 + 723 WP_004945948.1 RNA polymerase sigma factor FliA -
I6G46_RS02935 629537..630046 + 510 WP_004945946.1 flagella biosynthesis regulatory protein FliZ -
I6G46_RS02940 630172..631164 + 993 WP_197912567.1 D-cysteine desulfhydrase -
I6G46_RS02945 631278..632078 + 801 WP_006326095.1 cystine ABC transporter substrate-binding protein -
I6G46_RS02950 632078..632740 + 663 WP_006321381.1 cystine ABC transporter permease -
I6G46_RS02955 632744..633496 + 753 WP_062871168.1 L-cystine ABC transporter ATP-binding protein YecC -
I6G46_RS02960 633529..633942 - 414 WP_197912568.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6G46_RS02965 633972..634154 - 183 WP_073999815.1 type II toxin-antitoxin system HicA family toxin Toxin
I6G46_RS02970 634321..638292 - 3972 WP_197912569.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -
I6G46_RS02975 638395..638655 + 261 WP_197912570.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6976.28 Da        Isoelectric Point: 11.3081

>T183223 WP_073999815.1 NZ_CP065699:c634154-633972 [Serratia plymuthica]
VKSAELIRLLEREGWVLERIKGSHHQFKHPRSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Download         Length: 183 bp

>T183223 NZ_CP086796:43824-44150 [Pseudosulfitobacter pseudonitzschiae]
GTGAGGCGTGGTGAGCTGGTGACGGTCGCCCTTCAGGGCGACCACGGCAAGCCGCGTCCCGCGCTTGTGATCCAATCCGA
CCGGTTTCCGGACACCGCCACCACGACCGTCCTTCTGGTTACATCCACCTTGGTGGATGCGCCGTTGATTCGGCTGACGG
TCGAACCCTCTGCGGAGAACGGGTTGCGTATGCGATCACAGATCATGATCGACAAAGCCGTGACAGTTCGAACGGACAAG
CTGGGGAAAGCTTTCGGTCAGCTGGACGATACCGCCATGATCGAGGTGAACCGGGCACTAGCACTGTTTTTAGGAGTGGC
GGGGTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15198.93 Da        Isoelectric Point: 4.7180

>AT183223 WP_197912568.1 NZ_CP065699:c633942-633529 [Serratia plymuthica]
MFYPAYVHSDYDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDALNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQRHPGYGSRSAFLAAAARNELLKVD

Download         Length: 414 bp

>AT183223 NZ_CP086796:43609-43827 [Pseudosulfitobacter pseudonitzschiae]
ATGCCAACCTCTGTTTCTCACCGTGTCCAGAAGCGTCGCGATGCCTTGCGTGCCGCTGGTTTGCGCCCCGTCCAGATTTG
GGTGCCGGATACCCGCCGCCCCGGTTTCGAGGCTGAGTGCCGCCGCCAGGCTGCAATTGTAGCCAAGGCCGATCGCGCAG
ATGATACTCTGAACGATTTCCTGGATGCCTCCCTGGTCGATGTGGATGACTGGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References