Detailed information of TA system TA183221

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3666588..3667168
• Replicon: chromosome
• Accession: NZ_CP065695
• Organism: Delftia acidovorans strain FDAARGOS_891

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A9C0Y2
• Locus tag: I6G48_RS16905
• Protein ID: WP_012207614.1
• Coordinates: 3666588..3666968 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A9C0Y1
• Locus tag: I6G48_RS16910
• Protein ID: WP_012207613.1
• Coordinates: 3666965..3667168 (-)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G48_RS16890	3662619..3663635	+	1017	WP_012207617.1	porin	-
I6G48_RS16895	3663672..3664649	+	978	WP_043782962.1	tripartite tricarboxylate transporter substrate binding protein	-
I6G48_RS16900	3664661..3666538	+	1878	WP_012207615.1	CocE/NonD family hydrolase	-
I6G48_RS16905	3666588..3666968	-	381	WP_012207614.1	type II toxin-antitoxin system VapC family toxin	Toxin
I6G48_RS16910	3666965..3667168	-	204	WP_012207613.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
I6G48_RS16915	3667339..3668151	+	813	WP_012207612.1	glucose 1-dehydrogenase	-
I6G48_RS16920	3668261..3669937	+	1677	WP_012207611.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-114)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-43)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13931.34 Da
• Isoelectric Point: 8.5635

>T183221 WP_012207614.1 NZ_CP065695:c3666968-3666588 [Delftia acidovorans]
MNPVLVDTSVWIDHFRQGNPHLVQLLQQDMTLMHPLVLGELACGTPPARARTLADLQRLKPARQASMREVMALIEREQLF
GLGCGLVDMTLLASALMSSGASLWSLDKRLHALAQRFGIAYRPTGQ

Nucleotide

• Length: 381 bp

>T183221 NZ_CP086792:c36490-36239 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7485.58 Da
• Isoelectric Point: 4.5702

>AT183221 WP_012207613.1 NZ_CP065695:c3667168-3666965 [Delftia acidovorans]
MRTTVTIDDALYEEALELAEPEMDKADLFREAVKTFVRVQAAKRLAALGGSAPDMREIPRRPQGIEP

Nucleotide

• Length: 204 bp

>AT183221 NZ_CP086792:c36242-35976 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Structures

Toxin

• AlphaFold DB: A9C0Y2

Antitoxin

• AlphaFold DB: A9C0Y1