Detailed information of TA system TA183220

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3642157..3642836
• Replicon: chromosome
• Accession: NZ_CP065695
• Organism: Delftia acidovorans strain FDAARGOS_891

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A9C106
• Locus tag: I6G48_RS16780
• Protein ID: WP_012207638.1
• Coordinates: 3642411..3642836 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A9C107
• Locus tag: I6G48_RS16775
• Protein ID: WP_012207639.1
• Coordinates: 3642157..3642414 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G48_RS16750	3637895..3638689	-	795	WP_043782972.1	cobalt-precorrin-6A reductase	-
I6G48_RS16755	3638688..3639890	+	1203	WP_012207643.1	bifunctional cobalt-precorrin-7 (C(5))-methyltransferase/cobalt-precorrin-6B (C(15))-methyltransferase	-
I6G48_RS16760	3639887..3640384	+	498	WP_012207642.1	cobalamin biosynthesis protein	-
I6G48_RS16765	3640381..3641259	+	879	WP_012207641.1	precorrin-4 C(11)-methyltransferase	-
I6G48_RS16770	3641256..3642053	+	798	WP_012207640.1	precorrin-6A synthase (deacetylating)	-
I6G48_RS16775	3642157..3642414	+	258	WP_012207639.1	plasmid stability protein stbC	Antitoxin
I6G48_RS16780	3642411..3642836	+	426	WP_012207638.1	type II toxin-antitoxin system VapC family toxin	Toxin
I6G48_RS16785	3642875..3643924	-	1050	WP_012207637.1	NAD(P)-dependent alcohol dehydrogenase	-
I6G48_RS16790	3644066..3644959	+	894	WP_043782971.1	LysR family transcriptional regulator	-
I6G48_RS16795	3645117..3646574	+	1458	WP_012207635.1	chloride channel protein	-
I6G48_RS16800	3646690..3647202	+	513	WP_012207634.1	MgtC/SapB family protein	-
I6G48_RS16805	3647201..3647410	-	210	Protein_3303	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15291.58 Da
• Isoelectric Point: 6.2293

>T183220 WP_012207638.1 NZ_CP065695:3642411-3642836 [Delftia acidovorans]
MIVVDTNVISELWRLAPDSRVLAWMDAQAIETLHLSAVTVAELRYGIAAMPEGRRRTIYQERLEHEVLPAFAGRVLAFDL
DAAKAYADLMASAKTQGRAIAKADGYIAATAMAHGLVVATRDTRPFEAGGLQTINPWTAAP

Nucleotide

• Length: 426 bp

>T183220 NZ_CP086792:c36242-35976 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9403.56 Da
• Isoelectric Point: 6.2300

>AT183220 WP_012207639.1 NZ_CP065695:3642157-3642414 [Delftia acidovorans]
MANVTVRNLPDAVHRALRVRAAHHGRSTEAEIRDILEAAVRPEERVRLGSMLASIAREAGGLTDSEAEGFNRLRDRAPAE
PMDFE

Nucleotide

• Length: 258 bp

>AT183220 NZ_CP086792:c36490-36239 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Structures

Toxin

• AlphaFold DB: A9C106

Antitoxin

• AlphaFold DB: A9C107