Detailed information of TA system TA183219

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 2811822..2813278
• Replicon: chromosome
• Accession: NZ_CP065695
• Organism: Delftia acidovorans strain FDAARGOS_891

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: A9BQM7
• Locus tag: I6G48_RS13010
• Protein ID: WP_012202022.1
• Coordinates: 2811822..2812667 (-)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: A9BQM8
• Locus tag: I6G48_RS13015
• Protein ID: WP_012202023.1
• Coordinates: 2812664..2813278 (-)
• Length: 205 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G48_RS12985	2807157..2808320	+	1164	WP_012202017.1	ABC transporter substrate-binding protein	-
I6G48_RS12990	2808371..2809243	+	873	WP_012202018.1	branched-chain amino acid ABC transporter permease	-
I6G48_RS12995	2809247..2810332	+	1086	WP_012202019.1	branched-chain amino acid ABC transporter permease	-
I6G48_RS13000	2810325..2811083	+	759	WP_012202020.1	ABC transporter ATP-binding protein	-
I6G48_RS13005	2811088..2811789	+	702	WP_043780178.1	ABC transporter ATP-binding protein	-
I6G48_RS13010	2811822..2812667	-	846	WP_012202022.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6G48_RS13015	2812664..2813278	-	615	WP_012202023.1	AbiEi antitoxin N-terminal domain-containing protein	Antitoxin
I6G48_RS13020	2813386..2813859	-	474	WP_012202024.1	hotdog fold thioesterase	-
I6G48_RS13025	2813998..2815512	-	1515	WP_012202025.1	acetyl-CoA hydrolase/transferase family protein	-
I6G48_RS13030	2815720..2817027	-	1308	WP_012202026.1	NCS2 family nucleobase:cation symporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (35-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (12-57)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 31130.80 Da
• Isoelectric Point: 7.2653

>T183219 WP_012202022.1 NZ_CP065695:c2812667-2811822 [Delftia acidovorans]
MSRDIAASIRARLKQCADARRQDFNLTLTHYGLERLLYRLSISPHADSYLLKGALLFAIWYEQPHRPTRDADLLGFGLDD
VDSAVSAFREICGIAVDDGIAFDAASVRGTTIRKEAGYGEVRIDLRATLDGARITLQVDIGFGDAVTPSPQAIRYPVLLD
GLPAPQLRSYPKYTVVAEKLHAICLLGMANTRMKDYFDLWVLMTEGTLDPAELRRAMKATFERRQLALPAGLPAGLSDGF
SSDAAKQAQWAAFLKKNRLEALELAPVVARLREEFQQCGIF

Nucleotide

• Length: 846 bp

>T183219 NZ_CP086791:c10488-10237 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTACTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCTATCCACGACAAGCAGGAAGT
TGTCGTGACGCGCAAGAAGGGCGAGTCCGTTGTGGTCGTGTCCTTGGACACTTGGAACGCCGTCAACGAGACTTTGCACC
TGTTGTCCACACCGAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGAGCGTGAG
CTGACCGAGTGA

Antitoxin

Protein

• Length: 205 a.a.
• Molecular weight: 21868.45 Da
• Isoelectric Point: 9.5757

>AT183219 WP_012202023.1 NZ_CP065695:c2813278-2812664 [Delftia acidovorans]
MPAPGSALEQAVLALAEQRPLLRARDLAALGLPTMALSRLVAAGRLERVARGLYSLPGRPLSEHRSLAEVALRVPQGVVC
LLSALRVHGIGTQAPFEVWMAIPHHSPTPRIDQPALRAIRMSGAALSEGVETLQIDGVGVAVFNASKTVADCFKYRNKIG
LDVALEALRDGWAQGKLTADALWHYAAIDRVSNVMRPYLESIAA

Nucleotide

• Length: 615 bp

>AT183219 NZ_CP086791:c10240-9974 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGCTGGTTTTTTCGGATCAGGCCTGGGAAGATTATCAGTACTGGGTCAGCACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAATGCAAACGGACCCCCTTCAAAGGTTCCGGCTTGCCGGAACCTTTGAAGGGGGATTTGACAG
GCTGGTGGTCACGGCGAATTTCTCAGGAAGATCGAATGGTTTACCGGGTCAGTGGAACTGGCGACGGCCAAAGCTTAGAG
ATTGCGCAACTTCGGTTTCATTACTGA

Structures

Toxin

• AlphaFold DB: A9BQM7

Antitoxin

• AlphaFold DB: A9BQM8