Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2310349..2312032 Replicon chromosome
Accession NZ_CP065695
Organism Delftia acidovorans strain FDAARGOS_891

Toxin (Protein)


Gene name doc Uniprot ID A9BQI6
Locus tag I6G48_RS10740 Protein ID WP_012202882.1
Coordinates 2311178..2312032 (-) Length 285 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID F6ALN8
Locus tag I6G48_RS10735 Protein ID WP_012202883.1
Coordinates 2310349..2311155 (-) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G48_RS10715 2306664..2306939 + 276 WP_012202887.1 hypothetical protein -
I6G48_RS10720 2307218..2308405 - 1188 WP_012202886.1 IS481 family transposase -
I6G48_RS10725 2308630..2309385 - 756 WP_012202885.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
I6G48_RS10730 2309497..2310294 - 798 WP_043780656.1 aspartate dehydrogenase -
I6G48_RS10735 2310349..2311155 - 807 WP_012202883.1 IclR family transcriptional regulator Antitoxin
I6G48_RS10740 2311178..2312032 - 855 WP_012202882.1 alpha/beta fold hydrolase Toxin
I6G48_RS10745 2312047..2312577 - 531 WP_012202881.1 cupin domain-containing protein -
I6G48_RS10750 2312763..2313083 - 321 Protein_2118 Lrp/AsnC family transcriptional regulator -
I6G48_RS10755 2313077..2313295 + 219 Protein_2119 transporter -
I6G48_RS10760 2313364..2315043 - 1680 WP_012202878.1 long-chain-fatty-acid--CoA ligase -
I6G48_RS10765 2315200..2316021 - 822 WP_012202877.1 2,5-didehydrogluconate reductase DkgB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(43-270)

Antitoxin

Transcription regulator IclR, C-terminal

(137-255)


Sequences

Toxin        


Download         Length: 285 a.a.        Molecular weight: 29659.91 Da        Isoelectric Point: 6.7493

>T183218 WP_012202882.1 NZ_CP065695:c2312032-2311178 [Delftia acidovorans]
MTAQTLQRMEQRLQTQFPEHLIALPGGAQAAWREAGDTASDFAVVMLHGISSGAASWLDVALELAPRARVLAWDAPGYGR
STPLAPDAPTGADYARVLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGQLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Download         Length: 855 bp

>T183218 NZ_CP086791:c10240-9974 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGCTGGTTTTTTCGGATCAGGCCTGGGAAGATTATCAGTACTGGGTCAGCACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAATGCAAACGGACCCCCTTCAAAGGTTCCGGCTTGCCGGAACCTTTGAAGGGGGATTTGACAG
GCTGGTGGTCACGGCGAATTTCTCAGGAAGATCGAATGGTTTACCGGGTCAGTGGAACTGGCGACGGCCAAAGCTTAGAG
ATTGCGCAACTTCGGTTTCATTACTGA

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29330.45 Da        Isoelectric Point: 5.7085

>AT183218 WP_012202883.1 NZ_CP065695:c2311155-2310349 [Delftia acidovorans]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLENMGYLQRSGTEYRLGLSVL
RLGYDYLSTQPLAQLAEPVLQALCERLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRELFGGSELPQFSESTPRDVQQLQQLLLQDRERGYAMGEGFYEPGVSSIAAPVRDAQGRIIAGLGMAVAFTEIAPGR
MAHWVEQVREAAVELTGHLRTQHPGFLR

Download         Length: 807 bp

>AT183218 NZ_CP086791:c10488-10237 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTACTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCTATCCACGACAAGCAGGAAGT
TGTCGTGACGCGCAAGAAGGGCGAGTCCGTTGTGGTCGTGTCCTTGGACACTTGGAACGCCGTCAACGAGACTTTGCACC
TGTTGTCCACACCGAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGAGCGTGAG
CTGACCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9BQI6

Antitoxin

Source ID Structure
AlphaFold DB A0A031HDN8

References