Detailed information of TA system TA183216

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/upstrm_HI1419-dnstrm_HI1420
• Location: 1495265..1495854
• Replicon: chromosome
• Accession: NZ_CP065695
• Organism: Delftia acidovorans strain FDAARGOS_891

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A9BSX0
• Locus tag: I6G48_RS07015
• Protein ID: WP_012203615.1
• Coordinates: 1495265..1495561 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A9BSW9
• Locus tag: I6G48_RS07020
• Protein ID: WP_012203614.1
• Coordinates: 1495558..1495854 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G48_RS06995	1490418..1491353	+	936	WP_012203619.1	fatty acid desaturase	-
I6G48_RS07000	1491369..1493321	+	1953	WP_012203618.1	StlD/DarB family beta-ketosynthase	-
I6G48_RS07005	1493321..1494298	+	978	WP_012203617.1	hypothetical protein	-
I6G48_RS07010	1494534..1495217	+	684	WP_043780967.1	Crp/Fnr family transcriptional regulator	-
I6G48_RS07015	1495265..1495561	+	297	WP_012203615.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6G48_RS07020	1495558..1495854	+	297	WP_012203614.1	putative addiction module antidote protein	Antitoxin
I6G48_RS07025	1495883..1497640	-	1758	WP_012203613.1	GGDEF domain-containing phosphodiesterase	-
I6G48_RS07030	1497637..1499214	-	1578	WP_012203612.1	PAS domain-containing methyl-accepting chemotaxis protein	-
I6G48_RS07035	1499376..1499990	-	615	WP_012203611.1	SCO family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1422966..1495854	72888

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-89)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11232.01 Da
• Isoelectric Point: 10.0308

>T183216 WP_012203615.1 NZ_CP065695:1495265-1495561 [Delftia acidovorans]
MYSVIETEAFADWVDSIRDIPTRIRLRRRLGKAMRGNLGDVKSVGEGLWEMREFFGPGWRMYYIQRDHVLIVMLGGGDKS
SQAQDIAAARAMAREIKL

Nucleotide

• Length: 297 bp

>T183216 NZ_CP086790:c545657-545394 [Pseudosulfitobacter pseudonitzschiae]
ATGAAGTTCGAGTATGACCCTGACAAGAGTGCCGGGAACAAGGCCAAGCACGGCATCGACTTCGATGAAGCGCAAGCGCT
TTGGGAAGACCCGTGGCTGTTGGAGGCTCCCGCTCGAACAGATGACGAGCCGCGCTTTTTTGCAATAGGCATGATCAAGG
AACGGCATTGGTCAGCAGTTTGCACCTATCGCGGTGATATTATTCGGATCATCTCGGTGCGCCGCGCCAGAAAACAGGAG
ATTGAGCACTATGAAAGCACGTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10768.22 Da
• Isoelectric Point: 4.6151

>AT183216 WP_012203614.1 NZ_CP065695:1495558-1495854 [Delftia acidovorans]
MSNIKMRPFDMANYLGTEEEIVEYLRQALEDNDPAELAAALGDIARARGMTQLARDTGLSRESLYKSLSGERAPSSETLF
KVIQAMGFRLTIAPAASQ

Nucleotide

• Length: 297 bp

>AT183216 NZ_CP086790:c545407-545192 [Pseudosulfitobacter pseudonitzschiae]
ATGAAAGCACGTGAGTTCGATCAAAAATTTGACACAGGTGAGAACGTCAGCGATCTTGTGGACTGGTCCAAAGCTAGGCG
GACGAATACCCAGACGAAGCGAGTCAATGTGGATTTTCCGTCGTGGGTCGTTTCTGGTTTGGATCAGAAGGCAAAGCAGC
TCGGCGTTACTCGTCAGTCGCTCATCAAACTCTGGATCGCCGAGCGGCTCCAATGA

Structures

Toxin

• AlphaFold DB: A9BSX0

Antitoxin

• AlphaFold DB: A9BSW9