183215

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4516918..4517538 Replicon chromosome
Accession NZ_CP065693
Organism Enterobacter asburiae strain FDAARGOS_892

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag I6G49_RS22455 Protein ID WP_008499287.1
Coordinates 4517320..4517538 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag I6G49_RS22450 Protein ID WP_008499288.1
Coordinates 4516918..4517292 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G49_RS22440 4512045..4513238 + 1194 WP_029741963.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I6G49_RS22445 4513261..4516407 + 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit -
I6G49_RS22450 4516918..4517292 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
I6G49_RS22455 4517320..4517538 + 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
I6G49_RS22460 4517744..4518295 + 552 WP_023310599.1 maltose O-acetyltransferase -
I6G49_RS22465 4518413..4518880 + 468 WP_029741965.1 membrane protein -
I6G49_RS22470 4518852..4520312 - 1461 WP_059346263.1 PLP-dependent aminotransferase family protein -
I6G49_RS22475 4520414..4521124 + 711 WP_059346262.1 GNAT family N-acetyltransferase -
I6G49_RS22480 4521121..4521261 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
I6G49_RS22485 4521264..4521524 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T183215 WP_008499287.1 NZ_CP065693:4517320-4517538 [Enterobacter asburiae]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T183215 NZ_CP086789:39709-39984 [Pseudosulfitobacter pseudonitzschiae]
GTGCCTGACCTTGAATGGAAGGCATTGGCGGTCGCGGACCTGATGGCGATTGTTGACTATATCTCGGATGACAATCCCGA
TGCCGCAATTTCCCTGATGGATGACATTCAAGACAAGGTGCTTGGCCTTCTGACGCATCCCAAATCCGGCCGCCCCGGTA
GGGTGAACGACACGCGAGAGCTGGTGATCCGGCCCAACTATATCGTCGTCTATGCTGAAAACACGGCGGCGGTCACCATT
CTGCGCGTTCTTCATGCGGTGCAGATGTGGCCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT183215 WP_008499288.1 NZ_CP065693:4516918-4517292 [Enterobacter asburiae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT183215 NZ_CP086789:39423-39716 [Pseudosulfitobacter pseudonitzschiae]
ATGTCCGCTCAAACCTCGATGATTCATGTTCGTGTAGATGATCAGCTCAAGGCAAAGGCCACGGATGCCCTGTCCGGTGT
CGGCCTGACGTTGTCGGACGCCGTGCGCATCCTGCTGACCCGCGTGGCAGCAGAGGGTGGCTTGCCCGCAGGGTTGACGG
CAAATCCTGACGCCTACGATGCCTGGTTCCGCGCCAAGGTACAGGACGCATTGGCCGACGCAGCACCGGCCAAGCCGCAC
GATCAGGTGATGCGAGACGCGCGCGCCTTGATCGACGGCAAGCGCGGTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References