Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1939852..1940519 Replicon chromosome
Accession NZ_CP065693
Organism Enterobacter asburiae strain FDAARGOS_892

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag I6G49_RS09820 Protein ID WP_047358936.1
Coordinates 1939852..1940181 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag I6G49_RS09825 Protein ID WP_047358935.1
Coordinates 1940202..1940519 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G49_RS09780 1934882..1935286 + 405 WP_032660403.1 DNA-binding protein StpA -
I6G49_RS09785 1935325..1935504 - 180 WP_023308920.1 hypothetical protein -
I6G49_RS09790 1935584..1936105 - 522 WP_059347771.1 rhodanese family protein -
I6G49_RS09795 1936115..1936414 - 300 WP_029742056.1 metalloregulator ArsR/SmtB family transcription factor -
I6G49_RS09800 1936594..1936752 + 159 WP_023308917.1 YqaE/Pmp3 family membrane protein -
I6G49_RS09805 1936749..1937678 - 930 WP_029742057.1 LysR family transcriptional regulator -
I6G49_RS09810 1937961..1938658 + 698 Protein_1830 IS1 family transposase -
I6G49_RS09815 1938686..1939483 - 798 Protein_1831 integrase arm-type DNA-binding domain-containing protein -
I6G49_RS09820 1939852..1940181 - 330 WP_047358936.1 TA system toxin CbtA family protein Toxin
I6G49_RS09825 1940202..1940519 - 318 WP_047358935.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6G49_RS09830 1940538..1940759 - 222 WP_047358934.1 DUF987 domain-containing protein -
I6G49_RS09835 1940768..1941250 - 483 WP_032238502.1 DNA repair protein RadC -
I6G49_RS09840 1941259..1941711 - 453 WP_047358933.1 antirestriction protein -
I6G49_RS09845 1941797..1942033 - 237 WP_047358932.1 DUF905 domain-containing protein -
I6G49_RS09850 1942111..1942521 - 411 WP_047358931.1 hypothetical protein -
I6G49_RS09855 1942586..1943023 - 438 WP_038434461.1 hypothetical protein -
I6G49_RS09860 1943065..1943601 - 537 WP_047358930.1 DUF4339 domain-containing protein -
I6G49_RS09865 1943627..1944337 - 711 WP_047358929.1 DeoR family transcriptional regulator -
I6G49_RS09870 1944546..1945370 - 825 WP_047358928.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1927553..1949849 22296


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12344.43 Da        Isoelectric Point: 9.5732

>T183205 WP_047358936.1 NZ_CP065693:c1940181-1939852 [Enterobacter asburiae]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRKGF
SWQEQTPYLSVVDILRARRSSGLLKTNVK

Download         Length: 330 bp

>T183205 NZ_CP086776:23020-23271 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCGAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11837.43 Da        Isoelectric Point: 6.8407

>AT183205 WP_047358935.1 NZ_CP065693:c1940519-1940202 [Enterobacter asburiae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASITGKFSDAECFKLDVAFPHFISQMESMLTTGEMNPRHARCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT183205 NZ_CP086776:23268-23534 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References