Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1674976..1675633 Replicon chromosome
Accession NZ_CP065693
Organism Enterobacter asburiae strain FDAARGOS_892

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag I6G49_RS08415 Protein ID WP_021242050.1
Coordinates 1675223..1675633 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag I6G49_RS08410 Protein ID WP_010435322.1
Coordinates 1674976..1675242 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G49_RS08385 1670156..1671589 - 1434 WP_059347708.1 6-phospho-beta-glucosidase BglA -
I6G49_RS08390 1671706..1672437 - 732 WP_029739204.1 MurR/RpiR family transcriptional regulator -
I6G49_RS08395 1672489..1672800 + 312 WP_054830213.1 N(4)-acetylcytidine aminohydrolase -
I6G49_RS08400 1672966..1673625 + 660 WP_023309101.1 hemolysin III family protein -
I6G49_RS08405 1673701..1674681 - 981 WP_054830214.1 tRNA-modifying protein YgfZ -
I6G49_RS08410 1674976..1675242 + 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
I6G49_RS08415 1675223..1675633 + 411 WP_021242050.1 protein YgfX Toxin
I6G49_RS08420 1675640..1676161 - 522 WP_059347709.1 flavodoxin FldB -
I6G49_RS08425 1676263..1677159 + 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
I6G49_RS08430 1677188..1677901 + 714 WP_029740340.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6G49_RS08435 1677907..1679640 + 1734 WP_059347710.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T183204 WP_021242050.1 NZ_CP065693:1675223-1675633 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T183204 NZ_CP086775:c3194297-3194034 [Pseudosulfitobacter pseudonitzschiae]
ATGAAGTTCGAGTATGACCCTGACAAGAGTGCCGGGAACAAGGCCAAGCACGGCATCGACTTCGATGAAGCGCAAGCGCT
TTGGGAAGACCCGTGGCTGTTGGAGGCTCCCGCTCGAACAGATGACGAGCCGCGCTTTTTTGCAATAGGCATGATCAAGG
AACGGCATTGGTCAGCAGTTTGCACCTATCGCGGTGATATTATTCGGATCATCTCGGTGCGCCGCGCCAGAAAACAGGAG
ATTGAGCACTATGAAAGCACGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT183204 WP_010435322.1 NZ_CP065693:1674976-1675242 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT183204 NZ_CP086775:c3194047-3193832 [Pseudosulfitobacter pseudonitzschiae]
ATGAAAGCACGTGAGTTCGATCAAAAATTTGACACAGGTGAGAACGTCAGCGATCTTGTGGACTGGTCCAAAGCTAGGCG
GACGAATACCCAGACGAAGCGAGTCAATGTGGATTTTCCGTCGTGGGTCGTTTCTGGTTTGGATCAGAAGGCAAAGCAGC
TCGGCGTTACTCGTCAGTCGCTCATCAAACTCTGGATCGCCGAGCGGCTCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References