Detailed information of TA system TA183201

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 368877..369393
• Replicon: chromosome
• Accession: NZ_CP065693
• Organism: Enterobacter asburiae strain FDAARGOS_892

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8I1FZF0
• Locus tag: I6G49_RS02010
• Protein ID: WP_054829936.1
• Coordinates: 368877..369161 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V3EXX3
• Locus tag: I6G49_RS02015
• Protein ID: WP_008501400.1
• Coordinates: 369151..369393 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G49_RS01995	364154..365797	+	1644	WP_059347250.1	alpha,alpha-phosphotrehalase	-
I6G49_RS02000	366173..368311	+	2139	WP_023310191.1	anaerobic ribonucleoside-triphosphate reductase	-
I6G49_RS02005	368409..368873	+	465	WP_048977027.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
I6G49_RS02010	368877..369161	-	285	WP_054829936.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6G49_RS02015	369151..369393	-	243	WP_008501400.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I6G49_RS02020	369471..371381	-	1911	WP_059347251.1	BglG family transcription antiterminator	-
I6G49_RS02025	371401..372537	-	1137	WP_059347252.1	lactonase family protein	-
I6G49_RS02030	372574..373314	-	741	WP_029739262.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10908.72 Da
• Isoelectric Point: 10.1988

>T183201 WP_054829936.1 NZ_CP065693:c369161-368877 [Enterobacter asburiae]
MTYELAFDPRALKEWSKLGETVKDQFKKKLAEVLVNPRVESARLHGLPDCYKIKLRSQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Nucleotide

• Length: 285 bp

>T183201 NZ_CP086774:34689-34940 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTACTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCTATCCACGACAAGCAGGAAGT
TGTCGTGACGCGCAAGAAGGGCGAGTCCGTTGTGGTCGTGTCCTTGGACACTTGGAACGCCGTCAACGAGACTTTGCACC
TGTTGTCCACACCGAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGAGCGTGAG
CTGACCGAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8972.37 Da
• Isoelectric Point: 5.0651

>AT183201 WP_008501400.1 NZ_CP065693:c369393-369151 [Enterobacter asburiae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT183201 NZ_CP086774:34937-35203 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGCTGGTTTTTTCGGATCAGGCCTGGGAAGATTATCAGTACTGGGTCAGCACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAATGCAAACGGACCCCCTTCAAAGGTTCCGGCTTGCCGGAACCTTTGAAGGGGGATTTGACAG
GCTGGTGGTCACGGCGAATTTCTCAGGAAGATCGAATGGTTTACCGGGTCAGTGGAACTGGCGACGGCCAAAGCTTAGAG
ATTGCGCAACTTCGGTTTCATTACTGA

Structures

Antitoxin

• AlphaFold DB: V3EXX3