Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3887966..3888591 Replicon chromosome
Accession NZ_CP065688
Organism Serratia plymuthica strain FDAARGOS_895

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag I6G52_RS18120 Protein ID WP_063201925.1
Coordinates 3888409..3888591 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag I6G52_RS18115 Protein ID WP_063201920.1
Coordinates 3887966..3888379 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G52_RS18085 3883195..3883917 + 723 WP_004945948.1 RNA polymerase sigma factor FliA -
I6G52_RS18090 3883974..3884483 + 510 WP_063201911.1 flagella biosynthesis regulatory protein FliZ -
I6G52_RS18095 3884609..3885601 + 993 WP_063201914.1 D-cysteine desulfhydrase -
I6G52_RS18100 3885716..3886516 + 801 WP_063201917.1 cystine ABC transporter substrate-binding protein -
I6G52_RS18105 3886516..3887178 + 663 WP_006321381.1 cystine ABC transporter permease -
I6G52_RS18110 3887182..3887934 + 753 WP_062871168.1 L-cystine ABC transporter ATP-binding protein YecC -
I6G52_RS18115 3887966..3888379 - 414 WP_063201920.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6G52_RS18120 3888409..3888591 - 183 WP_063201925.1 type II toxin-antitoxin system HicA family toxin Toxin
I6G52_RS18125 3888758..3892726 - 3969 WP_063201928.1 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6893.14 Da        Isoelectric Point: 11.0382

>T183190 WP_063201925.1 NZ_CP065688:c3888591-3888409 [Serratia plymuthica]
VKSSELIRLLEREGWVLERIKGSHHQFKHPGSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Download         Length: 183 bp

>T183190 NZ_CP086762:53583-54053 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15092.85 Da        Isoelectric Point: 4.6961

>AT183190 WP_063201920.1 NZ_CP065688:c3888379-3887966 [Serratia plymuthica]
MFYPAYVHSDLDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDTLNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKVG

Download         Length: 414 bp

>AT183190 NZ_CP086762:53143-53586 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAAGTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACTGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References