Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 3189432..3189899 Replicon chromosome
Accession NZ_CP065688
Organism Serratia plymuthica strain FDAARGOS_895

Toxin (Protein)


Gene name relE Uniprot ID A0A1B1KUP0
Locus tag I6G52_RS14825 Protein ID WP_006316908.1
Coordinates 3189630..3189899 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U3Z4H1
Locus tag I6G52_RS14820 Protein ID WP_013814083.1
Coordinates 3189432..3189626 (+) Length 65 a.a.

Genomic Context

I6G52_RS14800I6G52_RS14805I6G52_RS14810I6G52_RS14820I6G52_RS14825I6G52_RS14840I6G52_RS14845I6G52_RS14815I6G52_RS14830I6G52_RS14835I6G52_RS14850I6G52_RS14855
Location: 3187616..3187981 (366 bp)
Type: Others
Protein ID: WP_063203195.1
Location: 3188102..3188317 (216 bp)
Type: Others
Protein ID: WP_183044542.1
Location: 3188307..3188657 (351 bp)
Type: Others
Protein ID: WP_063197303.1
Location: 3189432..3189626 (195 bp)
Type: Antitoxin
Protein ID: WP_013814083.1
Location: 3189630..3189899 (270 bp)
Type: Toxin
Protein ID: WP_006316908.1
Location: 3191884..3192510 (627 bp)
Type: Others
Protein ID: WP_006327216.1
Location: 3192711..3194000 (1290 bp)
Type: Others
Protein ID: WP_063197301.1
Location: 3188734..3189285 (552 bp)
Type: Others
Protein ID: WP_004951898.1
Location: 3189953..3190591 (639 bp)
Type: Others
Protein ID: WP_037433480.1
Location: 3190591..3191628 (1038 bp)
Type: Others
Protein ID: WP_006316901.1
Location: 3194050..3194298 (249 bp)
Type: Others
Protein ID: WP_004951888.1
Location: 3194337..3194852 (516 bp)
Type: Others
Protein ID: WP_006327215.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6G52_RS148003187616..3187981+366WP_063203195.1DUF596 domain-containing protein-
I6G52_RS148053188102..3188317+216WP_183044542.1DUF637 domain-containing protein-
I6G52_RS148103188307..3188657+351WP_063197303.1DUF596 domain-containing protein-
I6G52_RS148153188734..3189285-552WP_004951898.1spermidine N1-acetyltransferase-
I6G52_RS148203189432..3189626+195WP_013814083.1hypothetical proteinAntitoxin
I6G52_RS148253189630..3189899+270WP_006316908.1type II toxin-antitoxin system RelE/ParE family toxinToxin
I6G52_RS148303189953..3190591-639WP_037433480.1phosphoribosylglycinamide formyltransferase-
I6G52_RS148353190591..3191628-1038WP_006316901.1phosphoribosylformylglycinamidine cyclo-ligase-
I6G52_RS148403191884..3192510+627WP_006327216.1uracil phosphoribosyltransferase-
I6G52_RS148453192711..3194000+1290WP_063197301.1uracil permease-
I6G52_RS148503194050..3194298-249WP_004951888.1GlsB/YeaQ/YmgE family stress response membrane protein-
I6G52_RS148553194337..3194852-516WP_006327215.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10611.19 Da        Isoelectric Point: 6.0726

>T183189 WP_006316908.1 NZ_CP065688:3189630-3189899 [Serratia plymuthica]
MRIEWSREAQEELWNIIDYIDDRNPQAALILQREIETAVHSLSLNPFMYRLGRVDNTREIVVHPNYLIVYRIIGHIEVLG
VIHAKREYP

Download         Length: 270 bp

>T183189 NZ_CP086761:c5109211-5108828 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7443.65 Da        Isoelectric Point: 10.2045

>AT183189 WP_013814083.1 NZ_CP065688:3189432-3189626 [Serratia plymuthica]
MVIKTSLSTQPTAEVAEQGESYDRWFRAKIEAAINSEKPRIPHEQVMNEMQIRLAAKKKIRKME

Download         Length: 195 bp

>AT183189 NZ_CP086761:c5109453-5109211 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1B1KUP0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U3Z4H1

References