Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 3189432..3189899 Replicon chromosome
Accession NZ_CP065688
Organism Serratia plymuthica strain FDAARGOS_895

Toxin (Protein)


Gene name relE Uniprot ID A0A1B1KUP0
Locus tag I6G52_RS14825 Protein ID WP_006316908.1
Coordinates 3189630..3189899 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U3Z4H1
Locus tag I6G52_RS14820 Protein ID WP_013814083.1
Coordinates 3189432..3189626 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G52_RS14800 3187616..3187981 + 366 WP_063203195.1 DUF596 domain-containing protein -
I6G52_RS14805 3188102..3188317 + 216 WP_183044542.1 DUF637 domain-containing protein -
I6G52_RS14810 3188307..3188657 + 351 WP_063197303.1 DUF596 domain-containing protein -
I6G52_RS14815 3188734..3189285 - 552 WP_004951898.1 spermidine N1-acetyltransferase -
I6G52_RS14820 3189432..3189626 + 195 WP_013814083.1 hypothetical protein Antitoxin
I6G52_RS14825 3189630..3189899 + 270 WP_006316908.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G52_RS14830 3189953..3190591 - 639 WP_037433480.1 phosphoribosylglycinamide formyltransferase -
I6G52_RS14835 3190591..3191628 - 1038 WP_006316901.1 phosphoribosylformylglycinamidine cyclo-ligase -
I6G52_RS14840 3191884..3192510 + 627 WP_006327216.1 uracil phosphoribosyltransferase -
I6G52_RS14845 3192711..3194000 + 1290 WP_063197301.1 uracil permease -
I6G52_RS14850 3194050..3194298 - 249 WP_004951888.1 GlsB/YeaQ/YmgE family stress response membrane protein -
I6G52_RS14855 3194337..3194852 - 516 WP_006327215.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10611.19 Da        Isoelectric Point: 6.0726

>T183189 WP_006316908.1 NZ_CP065688:3189630-3189899 [Serratia plymuthica]
MRIEWSREAQEELWNIIDYIDDRNPQAALILQREIETAVHSLSLNPFMYRLGRVDNTREIVVHPNYLIVYRIIGHIEVLG
VIHAKREYP

Download         Length: 270 bp

>T183189 NZ_CP086761:c5109211-5108828 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7443.65 Da        Isoelectric Point: 10.2045

>AT183189 WP_013814083.1 NZ_CP065688:3189432-3189626 [Serratia plymuthica]
MVIKTSLSTQPTAEVAEQGESYDRWFRAKIEAAINSEKPRIPHEQVMNEMQIRLAAKKKIRKME

Download         Length: 195 bp

>AT183189 NZ_CP086761:c5109453-5109211 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KUP0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U3Z4H1

References