Detailed information of TA system TA183187

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2769475..2770144
• Replicon: chromosome
• Accession: NZ_CP065688
• Organism: Serratia plymuthica strain FDAARGOS_895

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S4YKD8
• Locus tag: I6G52_RS12900
• Protein ID: WP_006327725.1
• Coordinates: 2769722..2770144 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S4YS10
• Locus tag: I6G52_RS12895
• Protein ID: WP_004952428.1
• Coordinates: 2769475..2769741 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G52_RS12870	2764599..2765924	+	1326	WP_063200124.1	MHS family MFS transporter	-
I6G52_RS12875	2765974..2766582	-	609	WP_013814383.1	HD domain-containing protein	-
I6G52_RS12880	2766773..2767450	+	678	WP_004952439.1	hemolysin III family protein	-
I6G52_RS12885	2767613..2768110	+	498	WP_063200127.1	DUF2165 domain-containing protein	-
I6G52_RS12890	2768164..2769150	-	987	WP_063200130.1	tRNA-modifying protein YgfZ	-
I6G52_RS12895	2769475..2769741	+	267	WP_004952428.1	FAD assembly factor SdhE	Antitoxin
I6G52_RS12900	2769722..2770144	+	423	WP_006327725.1	protein YgfX	Toxin
I6G52_RS12905	2770144..2770839	+	696	WP_062868495.1	two-component system response regulator CreB	-
I6G52_RS12910	2770836..2772254	+	1419	WP_063200132.1	two-component system sensor histidine kinase CreC	-
I6G52_RS12915	2772339..2773703	+	1365	WP_063200135.1	cell envelope integrity protein CreD	-
I6G52_RS12920	2773741..2774259	-	519	WP_004952413.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16461.41 Da
• Isoelectric Point: 11.0260

>T183187 WP_006327725.1 NZ_CP065688:2769722-2770144 [Serratia plymuthica]
VAQWRCNVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLANKRLSWHGQ
EWLLAKQPWMPRYGILLTLQPTQGKKRRRLWLASDSMGKAEWRHLRQLLLHPSADDDEEP

Nucleotide

• Length: 423 bp

>T183187 NZ_CP086761:c4630226-4629942 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10446.90 Da
• Isoelectric Point: 5.0843

>AT183187 WP_004952428.1 NZ_CP065688:2769475-2769741 [Serratia plymuthica]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDQLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT183187 NZ_CP086761:c4630458-4630216 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: S4YKD8

Antitoxin

• AlphaFold DB: S4YS10