Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE(toxin)
Location 2117008..2117573 Replicon chromosome
Accession NZ_CP065688
Organism Serratia plymuthica strain FDAARGOS_895

Toxin (Protein)


Gene name relE Uniprot ID A0A2X4V4R7
Locus tag I6G52_RS09985 Protein ID WP_063200583.1
Coordinates 2117008..2117286 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A2X4VH61
Locus tag I6G52_RS09990 Protein ID WP_062868918.1
Coordinates 2117304..2117573 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G52_RS09965 2113173..2113511 - 339 WP_041416656.1 PTS lactose/cellobiose transporter subunit IIA -
I6G52_RS09970 2113868..2114437 + 570 WP_062868920.1 peptidylprolyl isomerase A -
I6G52_RS09975 2114597..2116282 + 1686 WP_037433755.1 sensor histidine kinase -
I6G52_RS09980 2116282..2117007 + 726 WP_063200586.1 two-component system response regulator BtsR -
I6G52_RS09985 2117008..2117286 - 279 WP_063200583.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G52_RS09990 2117304..2117573 - 270 WP_062868918.1 hypothetical protein Antitoxin
I6G52_RS09995 2117803..2119329 + 1527 WP_037433749.1 DUF853 family protein -
I6G52_RS10000 2119435..2120010 + 576 WP_006328493.1 aminodeoxychorismate synthase component II -
I6G52_RS10005 2120142..2121359 + 1218 WP_062868917.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10260.87 Da        Isoelectric Point: 8.5141

>T183186 WP_063200583.1 NZ_CP065688:c2117286-2117008 [Serratia plymuthica]
VTLKWTEPAIADRMAIYDYLETKNPAAAIEIDSLISATATRLSQNPSSGKPGRVPGTREMVIHHSYFLVYELINGLIIML
AVVHARRQWPAN

Download         Length: 279 bp

>T183186 NZ_CP086761:c4546019-4545630 [Klebsiella pneumoniae]
ATGCAAAAAATATCATCACACCCGATACGGGCGAATCAGCCCTGCCTGTCACCCATTGAAATCTGGCAGCGATTGCTTAC
TCATCTGTTATCGCAGCATTATGGCCTGACGCTGAATGACACACCGTTCAGTAATGACTCCACCATCCAGGAGCATATTG
ATGCCGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATATGAACTGGAAAGAATTGACCGCGATGGTTGC
ACTGTCATGGAAAAGTCACCGTTTATTACCAGTATCAATATTCTACGTGCCCGTAAGGCCTCAGGCCTAATGAAACGCAG
CAGTCACAAAACTGTTACCCGGGTAACGGCAGGCCATCATCAGCAGCTAAAAATCACTAAGGGTACTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10352.65 Da        Isoelectric Point: 7.0169

>AT183186 WP_062868918.1 NZ_CP065688:c2117573-2117304 [Serratia plymuthica]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVEAYF
AERRSKLTR

Download         Length: 270 bp

>AT183186 NZ_CP086761:c4546423-4546058 [Klebsiella pneumoniae]
ATGAATAATCACTCAGAATCCGGTACCACGCCGGAGAATCCTACCTGCCAGCAGTGGGGACTAAAGAGCACGATCACACC
CTGTTTTGGCGCTCGTCTGGTGCAGGAAGACTGCCGGATACATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GTGACAACGATACATTGCGCCTCGACCAAGCCTTTCCGTTGATGCTCAAACAACTGGAGTTGATGCTGACTAGCGGCGAG
CTCAATCCCCGCTATCAGCACTGCGTCACGCTTTACCACAACGGACTCACCTGCGAAGCCGACACACTCGGTTCCTGTGG
CTATGTCTACATTGCTATCTATCCTGAGCAGACTGAGCCGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X4V4R7

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4VH61

References