Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE(toxin)
Location 2117008..2117573 Replicon chromosome
Accession NZ_CP065688
Organism Serratia plymuthica strain FDAARGOS_895

Toxin (Protein)


Gene name relE Uniprot ID A0A2X4V4R7
Locus tag I6G52_RS09985 Protein ID WP_063200583.1
Coordinates 2117008..2117286 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A2X4VH61
Locus tag I6G52_RS09990 Protein ID WP_062868918.1
Coordinates 2117304..2117573 (-) Length 90 a.a.

Genomic Context

I6G52_RS09970I6G52_RS09975I6G52_RS09980I6G52_RS09995I6G52_RS10000I6G52_RS10005I6G52_RS09965I6G52_RS09985I6G52_RS09990
Location: 2113868..2114437 (570 bp)
Type: Others
Protein ID: WP_062868920.1
Location: 2114597..2116282 (1686 bp)
Type: Others
Protein ID: WP_037433755.1
Location: 2116282..2117007 (726 bp)
Type: Others
Protein ID: WP_063200586.1
Location: 2117803..2119329 (1527 bp)
Type: Others
Protein ID: WP_037433749.1
Location: 2119435..2120010 (576 bp)
Type: Others
Protein ID: WP_006328493.1
Location: 2120142..2121359 (1218 bp)
Type: Others
Protein ID: WP_062868917.1
Location: 2113173..2113511 (339 bp)
Type: Others
Protein ID: WP_041416656.1
Location: 2117008..2117286 (279 bp)
Type: Toxin
Protein ID: WP_063200583.1
Location: 2117304..2117573 (270 bp)
Type: Antitoxin
Protein ID: WP_062868918.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6G52_RS099652113173..2113511-339WP_041416656.1PTS lactose/cellobiose transporter subunit IIA-
I6G52_RS099702113868..2114437+570WP_062868920.1peptidylprolyl isomerase A-
I6G52_RS099752114597..2116282+1686WP_037433755.1sensor histidine kinase-
I6G52_RS099802116282..2117007+726WP_063200586.1two-component system response regulator BtsR-
I6G52_RS099852117008..2117286-279WP_063200583.1type II toxin-antitoxin system RelE/ParE family toxinToxin
I6G52_RS099902117304..2117573-270WP_062868918.1hypothetical proteinAntitoxin
I6G52_RS099952117803..2119329+1527WP_037433749.1DUF853 family protein-
I6G52_RS100002119435..2120010+576WP_006328493.1aminodeoxychorismate synthase component II-
I6G52_RS100052120142..2121359+1218WP_062868917.1aspartate aminotransferase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10260.87 Da        Isoelectric Point: 8.5141

>T183186 WP_063200583.1 NZ_CP065688:c2117286-2117008 [Serratia plymuthica]
VTLKWTEPAIADRMAIYDYLETKNPAAAIEIDSLISATATRLSQNPSSGKPGRVPGTREMVIHHSYFLVYELINGLIIML
AVVHARRQWPAN

Download         Length: 279 bp

>T183186 NZ_CP086761:c4546019-4545630 [Klebsiella pneumoniae]
ATGCAAAAAATATCATCACACCCGATACGGGCGAATCAGCCCTGCCTGTCACCCATTGAAATCTGGCAGCGATTGCTTAC
TCATCTGTTATCGCAGCATTATGGCCTGACGCTGAATGACACACCGTTCAGTAATGACTCCACCATCCAGGAGCATATTG
ATGCCGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATATGAACTGGAAAGAATTGACCGCGATGGTTGC
ACTGTCATGGAAAAGTCACCGTTTATTACCAGTATCAATATTCTACGTGCCCGTAAGGCCTCAGGCCTAATGAAACGCAG
CAGTCACAAAACTGTTACCCGGGTAACGGCAGGCCATCATCAGCAGCTAAAAATCACTAAGGGTACTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10352.65 Da        Isoelectric Point: 7.0169

>AT183186 WP_062868918.1 NZ_CP065688:c2117573-2117304 [Serratia plymuthica]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVEAYF
AERRSKLTR

Download         Length: 270 bp

>AT183186 NZ_CP086761:c4546423-4546058 [Klebsiella pneumoniae]
ATGAATAATCACTCAGAATCCGGTACCACGCCGGAGAATCCTACCTGCCAGCAGTGGGGACTAAAGAGCACGATCACACC
CTGTTTTGGCGCTCGTCTGGTGCAGGAAGACTGCCGGATACATTTTCTCGCTGACCGGGCCGGATTCAACGGTGCTTTCA
GTGACAACGATACATTGCGCCTCGACCAAGCCTTTCCGTTGATGCTCAAACAACTGGAGTTGATGCTGACTAGCGGCGAG
CTCAATCCCCGCTATCAGCACTGCGTCACGCTTTACCACAACGGACTCACCTGCGAAGCCGACACACTCGGTTCCTGTGG
CTATGTCTACATTGCTATCTATCCTGAGCAGACTGAGCCGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2X4V4R7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2X4VH61

References