Detailed information of TA system TA183185

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1513461..1513934
• Replicon: chromosome
• Accession: NZ_CP065688
• Organism: Serratia plymuthica strain FDAARGOS_895

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I6G52_RS07295
• Protein ID: WP_063202450.1
• Coordinates: 1513461..1513736 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2X4TR66
• Locus tag: I6G52_RS07300
• Protein ID: WP_062869225.1
• Coordinates: 1513737..1513934 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G52_RS07280	1508506..1508883	-	378	WP_063202448.1	AprI/Inh family metalloprotease inhibitor	-
I6G52_RS07285	1508939..1510402	-	1464	WP_062869227.1	serralysin family metalloprotease	-
I6G52_RS07290	1511085..1513400	+	2316	WP_063202476.1	zinc/cadmium/mercury/lead-transporting ATPase	-
I6G52_RS07295	1513461..1513736	-	276	WP_063202450.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
I6G52_RS07300	1513737..1513934	-	198	WP_062869225.1	hypothetical protein	Antitoxin
I6G52_RS07305	1513995..1514240	-	246	WP_004950955.1	sulfurtransferase TusA	-
I6G52_RS07310	1514461..1515126	+	666	WP_006323048.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
I6G52_RS07315	1515169..1515603	+	435	WP_063202452.1	GNAT family N-acetyltransferase	-
I6G52_RS07320	1515684..1516247	+	564	WP_004950949.1	DcrB family lipoprotein	-
I6G52_RS07325	1516296..1517495	-	1200	WP_063202454.1	anaerobic glycerol-3-phosphate dehydrogenase subunit C	-
I6G52_RS07330	1517492..1518745	-	1254	WP_063202456.1	glycerol-3-phosphate dehydrogenase subunit GlpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10660.56 Da
• Isoelectric Point: 11.2606

>T183185 WP_063202450.1 NZ_CP065688:c1513736-1513461 [Serratia plymuthica]
MLVIEWSRSARQDLADILLFIANDNPRAARKMKVLISEAILPAAEHPHIFRRGRVDGTHEIIVHPNYLLIYQVVADRIRV
MRVLHARRRYP

Nucleotide

• Length: 276 bp

>T183185 NZ_CP086761:c4518744-4518211 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCTGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7580.65 Da
• Isoelectric Point: 4.4488

>AT183185 WP_062869225.1 NZ_CP065688:c1513934-1513737 [Serratia plymuthica]
MVILRSPVVSEYETQEQTEIYDRWFREKVREAMDDPLPGISHDEVMAEMDALIAVAEARKKTKQV

Nucleotide

• Length: 198 bp

>AT183185 NZ_CP086761:c4519021-4518755 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
GGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2X4TR66