Detailed information of TA system TA183184

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1211310..1211837
• Replicon: chromosome
• Accession: NZ_CP065688
• Organism: Serratia plymuthica strain FDAARGOS_895

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A2X4X2J1
• Locus tag: I6G52_RS05795
• Protein ID: WP_063202072.1
• Coordinates: 1211310..1211585 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I6G52_RS05800
• Protein ID: WP_063202252.1
• Coordinates: 1211589..1211837 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G52_RS05755	1207018..1207398	-	381	WP_073972075.1	hypothetical protein	-
I6G52_RS05760	1207470..1207889	-	420	WP_063202090.1	hypothetical protein	-
I6G52_RS05765	1207904..1208284	-	381	WP_073972074.1	hypothetical protein	-
I6G52_RS05770	1208466..1208846	-	381	WP_063202083.1	hypothetical protein	-
I6G52_RS05775	1208843..1209364	-	522	WP_063202080.1	hypothetical protein	-
I6G52_RS05780	1209703..1210023	-	321	WP_063202076.1	hypothetical protein	-
I6G52_RS05785	1210020..1210157	-	138	WP_155729010.1	hypothetical protein	-
I6G52_RS05790	1210461..1211096	-	636	WP_013811336.1	carbonic anhydrase	-
I6G52_RS05795	1211310..1211585	-	276	WP_063202072.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6G52_RS05800	1211589..1211837	-	249	WP_063202252.1	ribbon-helix-helix domain-containing protein	Antitoxin
I6G52_RS05805	1212110..1212339	-	230	Protein_1130	integrase	-
I6G52_RS05810	1212927..1213190	+	264	WP_063202070.1	type II toxin-antitoxin system HigB family toxin	-
I6G52_RS05815	1213187..1214416	+	1230	WP_063202067.1	ImmA/IrrE family metallo-endopeptidase	-
I6G52_RS05820	1214430..1215563	+	1134	WP_063202064.1	beta family protein	-
I6G52_RS05825	1215744..1216133	-	390	WP_063202061.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1200682..1226549	25867

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-44)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11041.48 Da
• Isoelectric Point: 5.1450

>T183184 WP_063202072.1 NZ_CP065688:c1211585-1211310 [Serratia plymuthica]
MEIYWTLKAQDDLERIYRFALQYSRQHADDVLDRLIIGSAGLTMHPAIGIQQTRYEPREVRKVLFDDYEVHYELRDNAIY
IVDLWHTKEER

Nucleotide

• Length: 276 bp

>T183184 NZ_CP086761:3905865-3906083 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9048.37 Da
• Isoelectric Point: 7.2042

>AT183184 WP_063202252.1 NZ_CP065688:c1211837-1211589 [Serratia plymuthica]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTRMLAESERRHQSIQTGLADVDAGRVVSHSDMVDFANRLK
KT

Nucleotide

• Length: 249 bp

>AT183184 NZ_CP086761:3905464-3905838 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGAAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: A0A2X4X2J1