Detailed information of TA system TA183183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1204505..1206054
• Replicon: chromosome
• Accession: NZ_CP065688
• Organism: Serratia plymuthica strain FDAARGOS_895

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2X4X2K0
• Locus tag: I6G52_RS05740
• Protein ID: WP_063202100.1
• Coordinates: 1204505..1205803 (-)
• Length: 433 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6G52_RS05745
• Protein ID: WP_004953056.1
• Coordinates: 1205806..1206054 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G52_RS05715	1199689..1200501	-	813	WP_063202113.1	HNH endonuclease	-
I6G52_RS05720	1200815..1200907	+	93	Protein_1113	ash family protein	-
I6G52_RS05725	1200950..1201267	+	318	WP_063202107.1	hypothetical protein	-
I6G52_RS05730	1201441..1202421	-	981	WP_063202103.1	DUF4928 family protein	-
I6G52_RS05735	1202421..1203686	-	1266	WP_073972076.1	DNA (cytosine-5-)-methyltransferase	-
I6G52_RS05740	1204505..1205803	-	1299	WP_063202100.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6G52_RS05745	1205806..1206054	-	249	WP_004953056.1	helix-turn-helix domain-containing protein	Antitoxin
I6G52_RS05750	1206261..1206962	-	702	WP_063202097.1	hypothetical protein	-
I6G52_RS05755	1207018..1207398	-	381	WP_073972075.1	hypothetical protein	-
I6G52_RS05760	1207470..1207889	-	420	WP_063202090.1	hypothetical protein	-
I6G52_RS05765	1207904..1208284	-	381	WP_073972074.1	hypothetical protein	-
I6G52_RS05770	1208466..1208846	-	381	WP_063202083.1	hypothetical protein	-
I6G52_RS05775	1208843..1209364	-	522	WP_063202080.1	hypothetical protein	-
I6G52_RS05780	1209703..1210023	-	321	WP_063202076.1	hypothetical protein	-
I6G52_RS05785	1210020..1210157	-	138	WP_155729010.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1200682..1226549	25867

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (3-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 433 a.a.
• Molecular weight: 48251.25 Da
• Isoelectric Point: 6.1874

>T183183 WP_063202100.1 NZ_CP065688:c1205803-1204505 [Serratia plymuthica]
VDKLRVALNGTVVGTLEKHAGGAMSFVYHEEWLAQAGARAISLSLPLQPEPFRGDVVYNFFDNLLPDSEFIRSRLQARFR
TATKQPFDLLSSIGSDCVGAIQLYPEHADMAPVKQVNAVPVSDEEIEQLLLGYREAPLGMVAGTDDFRISLAGAQEKTAL
LWFGNQWYRPQGSTPTSHIIKLPIGHIAHNNLDLSESCENEWLCLRIAEQFGLPVAQAELARFGEQKVLIVERFDRRWAR
DNSWLIRLPQEDFCQALGIAPALKYEADGGPGIAAAMQLLMGSQQPLLDRDTFFKSQIVFWMLAAIDGHAKNFSLFIEQE
TAYRMTPLYDVLSGYPFMHARGIAPQKTKMAMAAIGKGRHYRWSQILPRHFISTARAVGYSEEKTLQVMADLKAQTEQAI
ANVEAMLPDEFPRSVSDAIFSGVRRQAERLLG

Nucleotide

• Length: 1299 bp

>T183183 NZ_CP086761:c2622579-2621257 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGGTTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCTATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9263.60 Da
• Isoelectric Point: 10.4887

>AT183183 WP_004953056.1 NZ_CP065688:c1206054-1205806 [Serratia plymuthica]
MKITSAKMLAHALRNERKKRNQSQSKTADSIGLKQATVSAFENNPDGTRLETLFKLLAALDLELQVTPRGKPVDPKTWDQ
EW

Nucleotide

• Length: 249 bp

>AT183183 NZ_CP086761:c2622845-2622579 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACATGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Toxin

• AlphaFold DB: A0A2X4X2K0