Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1204505..1206054 Replicon chromosome
Accession NZ_CP065688
Organism Serratia plymuthica strain FDAARGOS_895

Toxin (Protein)


Gene name hipA Uniprot ID A0A2X4X2K0
Locus tag I6G52_RS05740 Protein ID WP_063202100.1
Coordinates 1204505..1205803 (-) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag I6G52_RS05745 Protein ID WP_004953056.1
Coordinates 1205806..1206054 (-) Length 83 a.a.

Genomic Context

I6G52_RS05720I6G52_RS05725I6G52_RS05715I6G52_RS05730I6G52_RS05735I6G52_RS05740I6G52_RS05745I6G52_RS05750I6G52_RS05755I6G52_RS05760I6G52_RS05765I6G52_RS05770I6G52_RS05775I6G52_RS05780I6G52_RS05785
Location: 1200815..1200907 (93 bp)
Type: Others
Protein ID: Protein_1113
Location: 1200950..1201267 (318 bp)
Type: Others
Protein ID: WP_063202107.1
Location: 1199689..1200501 (813 bp)
Type: Others
Protein ID: WP_063202113.1
Location: 1201441..1202421 (981 bp)
Type: Others
Protein ID: WP_063202103.1
Location: 1202421..1203686 (1266 bp)
Type: Others
Protein ID: WP_073972076.1
Location: 1204505..1205803 (1299 bp)
Type: Toxin
Protein ID: WP_063202100.1
Location: 1205806..1206054 (249 bp)
Type: Antitoxin
Protein ID: WP_004953056.1
Location: 1206261..1206962 (702 bp)
Type: Others
Protein ID: WP_063202097.1
Location: 1207018..1207398 (381 bp)
Type: Others
Protein ID: WP_073972075.1
Location: 1207470..1207889 (420 bp)
Type: Others
Protein ID: WP_063202090.1
Location: 1207904..1208284 (381 bp)
Type: Others
Protein ID: WP_073972074.1
Location: 1208466..1208846 (381 bp)
Type: Others
Protein ID: WP_063202083.1
Location: 1208843..1209364 (522 bp)
Type: Others
Protein ID: WP_063202080.1
Location: 1209703..1210023 (321 bp)
Type: Others
Protein ID: WP_063202076.1
Location: 1210020..1210157 (138 bp)
Type: Others
Protein ID: WP_155729010.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6G52_RS057151199689..1200501-813WP_063202113.1HNH endonuclease-
I6G52_RS057201200815..1200907+93Protein_1113ash family protein-
I6G52_RS057251200950..1201267+318WP_063202107.1hypothetical protein-
I6G52_RS057301201441..1202421-981WP_063202103.1DUF4928 family protein-
I6G52_RS057351202421..1203686-1266WP_073972076.1DNA (cytosine-5-)-methyltransferase-
I6G52_RS057401204505..1205803-1299WP_063202100.1type II toxin-antitoxin system HipA family toxinToxin
I6G52_RS057451205806..1206054-249WP_004953056.1helix-turn-helix domain-containing proteinAntitoxin
I6G52_RS057501206261..1206962-702WP_063202097.1hypothetical protein-
I6G52_RS057551207018..1207398-381WP_073972075.1hypothetical protein-
I6G52_RS057601207470..1207889-420WP_063202090.1hypothetical protein-
I6G52_RS057651207904..1208284-381WP_073972074.1hypothetical protein-
I6G52_RS057701208466..1208846-381WP_063202083.1hypothetical protein-
I6G52_RS057751208843..1209364-522WP_063202080.1hypothetical protein-
I6G52_RS057801209703..1210023-321WP_063202076.1hypothetical protein-
I6G52_RS057851210020..1210157-138WP_155729010.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1200682..122654925867


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(3-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 48251.25 Da        Isoelectric Point: 6.1874

>T183183 WP_063202100.1 NZ_CP065688:c1205803-1204505 [Serratia plymuthica]
VDKLRVALNGTVVGTLEKHAGGAMSFVYHEEWLAQAGARAISLSLPLQPEPFRGDVVYNFFDNLLPDSEFIRSRLQARFR
TATKQPFDLLSSIGSDCVGAIQLYPEHADMAPVKQVNAVPVSDEEIEQLLLGYREAPLGMVAGTDDFRISLAGAQEKTAL
LWFGNQWYRPQGSTPTSHIIKLPIGHIAHNNLDLSESCENEWLCLRIAEQFGLPVAQAELARFGEQKVLIVERFDRRWAR
DNSWLIRLPQEDFCQALGIAPALKYEADGGPGIAAAMQLLMGSQQPLLDRDTFFKSQIVFWMLAAIDGHAKNFSLFIEQE
TAYRMTPLYDVLSGYPFMHARGIAPQKTKMAMAAIGKGRHYRWSQILPRHFISTARAVGYSEEKTLQVMADLKAQTEQAI
ANVEAMLPDEFPRSVSDAIFSGVRRQAERLLG

Download         Length: 1299 bp

>T183183 NZ_CP086761:c2622579-2621257 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGGTTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCTATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9263.60 Da        Isoelectric Point: 10.4887

>AT183183 WP_004953056.1 NZ_CP065688:c1206054-1205806 [Serratia plymuthica]
MKITSAKMLAHALRNERKKRNQSQSKTADSIGLKQATVSAFENNPDGTRLETLFKLLAALDLELQVTPRGKPVDPKTWDQ
EW

Download         Length: 249 bp

>AT183183 NZ_CP086761:c2622845-2622579 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACATGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2X4X2K0

Antitoxin

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Source
ID
Structure
No matching records found

References