183182

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 816792..817348 Replicon chromosome
Accession NZ_CP065688
Organism Serratia plymuthica strain FDAARGOS_895

Toxin (Protein)


Gene name parE Uniprot ID A0A2X4UAE5
Locus tag I6G52_RS03920 Protein ID WP_063202630.1
Coordinates 817058..817348 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X4TZF9
Locus tag I6G52_RS03915 Protein ID WP_063202628.1
Coordinates 816792..817070 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G52_RS03890 812133..812972 - 840 WP_006323781.1 MurR/RpiR family transcriptional regulator -
I6G52_RS03895 813117..814703 + 1587 WP_063202668.1 gamma-glutamyltransferase -
I6G52_RS03900 814728..814919 + 192 WP_006322394.1 oxalurate catabolism protein HpxX -
I6G52_RS03905 814916..816316 + 1401 WP_063202626.1 AtzE family amidohydrolase -
I6G52_RS03910 816320..816706 + 387 WP_004949013.1 oxalurate catabolism protein HpxZ -
I6G52_RS03915 816792..817070 + 279 WP_063202628.1 CopG family ribbon-helix-helix protein Antitoxin
I6G52_RS03920 817058..817348 + 291 WP_063202630.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G52_RS03925 817358..818242 - 885 WP_063202632.1 siderophore-interacting protein -
I6G52_RS03930 818248..819471 - 1224 WP_063202634.1 MFS transporter -
I6G52_RS03935 819609..821354 + 1746 WP_063202637.1 aerobactin synthase IucA -
I6G52_RS03940 821351..822301 + 951 WP_063202639.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-93)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10904.65 Da        Isoelectric Point: 9.5469

>T183182 WP_063202630.1 NZ_CP065688:817058-817348 [Serratia plymuthica]
VPQLIWTPAALLDVQQLYRFLAEKDLNSAKRAVATIRNCIKIIAHQPHIGRPAKDMAPEFREWPIDFGNSGYLVLYRFNG
VTAVILAIRHQSETGY

Download         Length: 291 bp

>T183182 NZ_CP086761:1853136-1853238 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10649.73 Da        Isoelectric Point: 5.5193

>AT183182 WP_063202628.1 NZ_CP065688:816792-817070 [Serratia plymuthica]
MATATSIKIDDELKQRVQHIAAAHQRSAHWIMREAIREYVEREEKREAVRNDALQAWETYQANGKHLTQHEADGWLSDLE
KGDDTEIPGCHN

Download         Length: 279 bp

>AT183182 NZ_CP086761:c1853245-1853100 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X4UAE5

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4TZF9

References