183181

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 573054..573676 Replicon chromosome
Accession NZ_CP065688
Organism Serratia plymuthica strain FDAARGOS_895

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag I6G52_RS02760 Protein ID WP_006322256.1
Coordinates 573473..573676 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag I6G52_RS02755 Protein ID WP_004949348.1
Coordinates 573054..573422 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G52_RS02725 569095..569349 + 255 WP_004949355.1 type B 50S ribosomal protein L31 -
I6G52_RS02730 569362..569502 + 141 WP_004949353.1 type B 50S ribosomal protein L36 -
I6G52_RS02735 569618..570496 - 879 WP_063198026.1 metal ABC transporter substrate-binding protein -
I6G52_RS02740 570522..571379 - 858 WP_063198028.1 metal ABC transporter permease -
I6G52_RS02745 571376..572089 - 714 WP_062869870.1 ABC transporter ATP-binding protein -
I6G52_RS02750 572541..572894 + 354 WP_063198033.1 hypothetical protein -
I6G52_RS02755 573054..573422 + 369 WP_004949348.1 Hha toxicity modulator TomB Antitoxin
I6G52_RS02760 573473..573676 + 204 WP_006322256.1 hemolysin expression modulator Hha Toxin
I6G52_RS02765 573917..574453 - 537 WP_006323971.1 cytochrome b/b6 domain-containing protein -
I6G52_RS02770 574514..575935 - 1422 WP_062869867.1 N-acetylglucosamine-binding protein GbpA -
I6G52_RS02775 576215..576589 + 375 WP_063198035.1 type II secretion system pilot lipoprotein GspS -
I6G52_RS02780 576586..577416 - 831 WP_073972022.1 A24 family peptidase -
I6G52_RS02785 577449..577910 - 462 WP_063198037.1 type II secretion system protein M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 572568..589372 16804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T183181 WP_006322256.1 NZ_CP065688:573473-573676 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T183181 NZ_CP086761:786512-786922 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT183181 WP_004949348.1 NZ_CP065688:573054-573422 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp

>AT183181 NZ_CP086761:786265-786531 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KM53

Antitoxin

Source ID Structure
AlphaFold DB S4YKH5

References