183180

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 63943..64499 Replicon chromosome
Accession NZ_CP065688
Organism Serratia plymuthica strain FDAARGOS_895

Toxin (Protein)


Gene name ccdB Uniprot ID A0A7U4DW07
Locus tag I6G52_RS00240 Protein ID WP_013812173.1
Coordinates 63943..64260 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2X4U7C9
Locus tag I6G52_RS00245 Protein ID WP_063199959.1
Coordinates 64263..64499 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G52_RS00220 59714..60871 - 1158 WP_062870253.1 YbfB/YjiJ family MFS transporter -
I6G52_RS00225 60979..61896 + 918 WP_063199956.1 LysR family transcriptional regulator -
I6G52_RS00230 61925..63052 + 1128 WP_062870249.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
I6G52_RS00235 63067..63909 + 843 WP_004942338.1 S-formylglutathione hydrolase -
I6G52_RS00240 63943..64260 - 318 WP_013812173.1 CcdB family protein Toxin
I6G52_RS00245 64263..64499 - 237 WP_063199959.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
I6G52_RS00250 64644..65552 - 909 WP_174523958.1 glutathione ABC transporter permease GsiD -
I6G52_RS00255 65562..66482 - 921 WP_062870247.1 glutathione ABC transporter permease GsiC -
I6G52_RS00260 66535..68073 - 1539 WP_004942332.1 glutathione ABC transporter substrate-binding protein GsiB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11972.92 Da        Isoelectric Point: 5.8267

>T183180 WP_013812173.1 NZ_CP065688:c64260-63943 [Serratia plymuthica]
MQFTVYANTGKSAVYPLLLDVTNDIIEQLNRRVMIPLLPIEKYPASTRPERLNPLVRLVDDNEYAVMTHEMASIPVRILG
AEFCDASQYRTKVKAAIDFLFDGIR

Download         Length: 318 bp

>T183180 NZ_CP065688:c64260-63943 [Serratia plymuthica]
ATGCAATTTACGGTATACGCGAATACGGGGAAAAGCGCAGTCTATCCTCTGCTGCTTGATGTGACGAACGATATCATCGA
GCAATTAAATCGCCGAGTTATGATCCCGTTATTACCCATTGAAAAGTATCCGGCCAGTACTCGCCCGGAACGCTTGAACC
CTTTGGTCAGGCTGGTGGATGACAACGAGTACGCCGTTATGACTCATGAGATGGCAAGTATTCCCGTTCGTATCCTGGGC
GCTGAATTTTGCGATGCTTCCCAATACCGAACCAAGGTGAAAGCCGCAATAGATTTTCTTTTCGACGGTATCAGATGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9152.24 Da        Isoelectric Point: 6.7189

>AT183180 WP_063199959.1 NZ_CP065688:c64499-64263 [Serratia plymuthica]
MPVKQRTTQSVTMAVERSLLSRAREAGINLSTTLNTALDAELRQHEMRKWKEENREAIDALNRFHEEHGCFSDEYRTF

Download         Length: 237 bp

>AT183180 NZ_CP065688:c64499-64263 [Serratia plymuthica]
ATGCCAGTAAAACAACGAACGACCCAAAGCGTTACCATGGCGGTGGAACGCAGTTTACTGAGCCGTGCACGTGAGGCGGG
CATTAACCTCAGTACTACGCTGAATACTGCTTTGGATGCCGAATTGCGTCAGCATGAGATGAGGAAATGGAAGGAAGAAA
ACCGAGAAGCGATCGATGCTTTAAATCGTTTTCATGAAGAACATGGCTGTTTCAGTGACGAATACAGGACGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4DW07

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4U7C9

References