Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 766672..768437 Replicon chromosome
Accession NZ_CP065687
Organism Burkholderia humptydooensis strain FDAARGOS_899

Toxin (Protein)


Gene name doc Uniprot ID A0A7U4SUI5
Locus tag I6G56_RS23480 Protein ID WP_006027423.1
Coordinates 767523..768437 (-) Length 305 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A7U4PAC5
Locus tag I6G56_RS23475 Protein ID WP_006027422.1
Coordinates 766672..767526 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G56_RS23455 761888..763378 - 1491 WP_006027418.1 aldehyde dehydrogenase -
I6G56_RS23460 763404..764219 - 816 WP_006027419.1 aspartate dehydrogenase -
I6G56_RS23465 764212..765885 - 1674 WP_043282768.1 thiamine pyrophosphate-binding protein -
I6G56_RS23470 765878..766675 - 798 WP_006027421.1 SDR family oxidoreductase -
I6G56_RS23475 766672..767526 - 855 WP_006027422.1 IclR family transcriptional regulator Antitoxin
I6G56_RS23480 767523..768437 - 915 WP_006027423.1 alpha/beta fold hydrolase Toxin
I6G56_RS23485 768454..768981 - 528 WP_009914832.1 cupin domain-containing protein -
I6G56_RS23490 769020..769790 - 771 WP_006027425.1 SDR family oxidoreductase -
I6G56_RS23495 769787..770854 - 1068 WP_006027426.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
I6G56_RS23500 770889..771200 - 312 WP_006027427.1 hypothetical protein -
I6G56_RS23505 771202..771519 - 318 WP_009914826.1 non-heme iron oxygenase ferredoxin subunit -
I6G56_RS23510 771954..773042 + 1089 WP_009914825.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(57-287)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 305 a.a.        Molecular weight: 31147.07 Da        Isoelectric Point: 7.1483

>T183179 WP_006027423.1 NZ_CP065687:c768437-767523 [Burkholderia humptydooensis]
MSAISTTTAGASAMPFAALLERFAERHAAAGDAGTIGYREAGESYGERTEQAGRDPVVLLHGIGSGAASWVRQLDALGAT
RRALAWDAPGYGASSRVAAGSPVAADYAASLAAWLDALRIERCVLVGHSLGAIVAGAFARIASERLAGLLLISPAGGYGG
APADVRAERRDSRLALLASLGPQGLADERSANMLSAHASDTARAWVHWNMARIAPAGYAQAAHLLANADLASDLVHYRGR
VAVAVGGDDAITPPAACERIARAARVGLQVIPRAGHAGYVEAPDAYSALIDAFCRQCDGSRGAT

Download         Length: 915 bp

>T183179 NZ_CP086761:329170-329538 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31002.47 Da        Isoelectric Point: 7.4665

>AT183179 WP_006027422.1 NZ_CP065687:c767526-766672 [Burkholderia humptydooensis]
MSEPLLKDADNAKNDSTYVVPGLERGLRVLAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIEGLRDATGFTAHIVIRDGRDVVFVAKAQNAGHAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAELRALYPERELERVTKATPETVDALFDVIRADARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVADGLIEKVVRAAGGLSRRLNYRADDENTYLKALGLR

Download         Length: 855 bp

>AT183179 NZ_CP086761:328952-329173 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCTGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4SUI5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4PAC5

References