Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 591784..592439 Replicon chromosome
Accession NZ_CP065687
Organism Burkholderia humptydooensis strain FDAARGOS_899

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag I6G56_RS22655 Protein ID WP_006027262.1
Coordinates 592143..592439 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag I6G56_RS22650 Protein ID WP_004202809.1
Coordinates 591784..592140 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G56_RS22630 586911..587921 - 1011 WP_006027258.1 phage major capsid protein, P2 family -
I6G56_RS22635 587966..588775 - 810 WP_006027259.1 GPO family capsid scaffolding protein -
I6G56_RS22640 588919..590688 + 1770 WP_006027260.1 terminase ATPase subunit family protein -
I6G56_RS22645 590685..591740 + 1056 WP_006027261.1 phage portal protein -
I6G56_RS22650 591784..592140 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
I6G56_RS22655 592143..592439 - 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G56_RS22660 593104..594219 - 1116 WP_041861678.1 DUF3396 domain-containing protein -
I6G56_RS22665 594206..594970 - 765 WP_006027264.1 VRR-NUC domain-containing protein -
I6G56_RS22670 594967..595500 - 534 WP_006027265.1 PAAR domain-containing protein -
I6G56_RS22675 595603..595725 - 123 WP_009914987.1 hypothetical protein -
I6G56_RS22680 595959..596612 - 654 WP_009914986.1 AAA family ATPase -
I6G56_RS22685 596702..596908 - 207 WP_006027267.1 ogr/Delta-like zinc finger family protein -
I6G56_RS22690 596905..597171 - 267 WP_006027268.1 ogr/Delta-like zinc finger family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 567131..609573 42442


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T183178 WP_006027262.1 NZ_CP065687:c592439-592143 [Burkholderia humptydooensis]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T183178 NZ_CP086760:c1108083-1107799 [Helicobacter pylori]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATCATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT183178 WP_004202809.1 NZ_CP065687:c592140-591784 [Burkholderia humptydooensis]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT183178 NZ_CP086760:c1108456-1108064 [Helicobacter pylori]
ATGCCTAATTCTCCCACCAAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAATCTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGAAGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAAGAAGCCATGAGAGAAGCGTTAAATGGGGTTAATCTCACTCAAATTGATAG
TTTAGATGATCTTACAAACGAGTTAAAAAGAGAAAATGGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References