Detailed information of TA system TA183173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 364912..366692
• Replicon: chromosome
• Accession: NZ_CP065684
• Organism: Burkholderia oklahomensis strain FDAARGOS_900

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6G57_RS20680
• Protein ID: WP_010109598.1
• Coordinates: 365343..366692 (+)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6G57_RS20675
• Protein ID: WP_010109597.1
• Coordinates: 364912..365346 (+)
• Length: 145 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G57_RS20660	361568..363940	-	2373	WP_041282198.1	cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB	-
I6G57_RS20665	364162..364472	+	311	Protein_310	hypothetical protein	-
I6G57_RS20670	364641..364841	+	201	WP_124072353.1	hypothetical protein	-
I6G57_RS20675	364912..365346	+	435	WP_010109597.1	helix-turn-helix domain-containing protein	Antitoxin
I6G57_RS20680	365343..366692	+	1350	WP_010109598.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6G57_RS20685	366969..367412	-	444	WP_010109600.1	hypothetical protein	-
I6G57_RS20690	367648..368562	-	915	WP_010109602.1	LysR family transcriptional regulator	-
I6G57_RS20695	368715..369668	+	954	WP_010109604.1	agmatinase	-
I6G57_RS20700	369923..370090	+	168	WP_162474159.1	hypothetical protein	-
I6G57_RS20705	370090..371490	+	1401	WP_010109605.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (12-112)

Antitoxin

• Cro/C1-type helix-turn-helix domain (22-71)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 49883.80 Da
• Isoelectric Point: 8.7644

>T183173 WP_010109598.1 NZ_CP065684:365343-366692 [Burkholderia oklahomensis]
VSARRGTRTARLHLWMNGLPVGYWEHARDGERLVYFDEWIADPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPI
RRRIAMRYRTGGTSPFELLSTLGRDCVGALQMLPPGETPDDLERIRGRALADADIARLLREITSAPQAGQHEPLDDLRLS
IAGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCSKIVAAYGLPVAHCDIAHFDDQKALV
VERFDRKPSSDARWILRLPQEDMCQATGTSAFDKYQADGGPGIEAIMDVLAGSEHTADRYAFFATQIVFWLLAATDGHAK
NFSIAHLPGNRFRSTPLYDVLSAHPVIGRGANQLPMQRARLAMGVRGKNIHYPINQIQRRHWIAQGQRVGFAPAEVDDMI
DALTARTAGVVDEVSARLPRDFPRDVADAVFSGMLRLNAKLAASSPTRA

Nucleotide

• Length: 1350 bp

>T183173 NZ_CP086728:c1343516-1343247 [Streptococcus parasuis]
ATGGCTTATAAACTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTAGGGATGATGCTTGC
TAAGGATTTGAAAAAAAGATTGGACGGTTTGGAAAATCCAAGACAGTTTGGCAAGGCCTTGGTAGGAGACTATAAGGGCC
TGTGGCGGTATAGAGTGGGGAATTATCGTATAATTTGCGATATTATTGATAACAAAATGGTCATCTTAGCTCTTGAAATG
GGGCATCGGAAAGACATTTATCGGAAATGA

Antitoxin

Protein

• Length: 145 a.a.
• Molecular weight: 15552.15 Da
• Isoelectric Point: 11.9043

>AT183173 WP_010109597.1 NZ_CP065684:364912-365346 [Burkholderia oklahomensis]
MAITIEHEIKTLGQLRPILRGFRKAAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRVLDVELTLTLTHVYVA
PAKPAAKQTVAAPARKAVKTVGSGRVAAKRPASPTSQSAPGPHAAERLPRSPRKRAAPKKREDW

Nucleotide

• Length: 435 bp

>AT183173 NZ_CP086728:c1343733-1343506 [Streptococcus parasuis]
ATGGGAATTGTTTCTTTGCGATTAAATGAAACAGAAGAAGAAATTTTCAGAAGCTATGCCATTCATACTGGAAAAAGCCT
GTCTGAGTTATTCAAATCAGCACTTATTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTGCTTGCGGAGTTAGAAGATGGCTTATAA