Detailed information of TA system TA183167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4886894..4887519
• Replicon: chromosome
• Accession: NZ_CP065673
• Organism: Serratia plymuthica strain FDAARGOS_907

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: I6G64_RS22860
• Protein ID: WP_063201925.1
• Coordinates: 4887337..4887519 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: I6G64_RS22855
• Protein ID: WP_063201920.1
• Coordinates: 4886894..4887307 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G64_RS22825	4882123..4882845	+	723	WP_004945948.1	RNA polymerase sigma factor FliA	-
I6G64_RS22830	4882902..4883411	+	510	WP_063201911.1	flagella biosynthesis regulatory protein FliZ	-
I6G64_RS22835	4883537..4884529	+	993	WP_063201914.1	D-cysteine desulfhydrase	-
I6G64_RS22840	4884644..4885444	+	801	WP_063201917.1	cystine ABC transporter substrate-binding protein	-
I6G64_RS22845	4885444..4886106	+	663	WP_006321381.1	cystine ABC transporter permease	-
I6G64_RS22850	4886110..4886862	+	753	WP_062871168.1	L-cystine ABC transporter ATP-binding protein YecC	-
I6G64_RS22855	4886894..4887307	-	414	WP_063201920.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6G64_RS22860	4887337..4887519	-	183	WP_063201925.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6G64_RS22865	4887686..4891654	-	3969	WP_063201928.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6893.14 Da
• Isoelectric Point: 11.0382

>T183167 WP_063201925.1 NZ_CP065673:c4887519-4887337 [Serratia plymuthica]
VKSSELIRLLEREGWVLERIKGSHHQFKHPGSRLVITVPHPRKDLKPGTLRQIMKDAGLC

Nucleotide

• Length: 183 bp

>T183167 NZ_CP086726:1822717-1822818 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15092.85 Da
• Isoelectric Point: 4.6961

>AT183167 WP_063201920.1 NZ_CP065673:c4887307-4886894 [Serratia plymuthica]
MFYPAYVHSDLDGSASGFFPDVPGCYFAGDTLDKAFEDAKGALDAHFELLSEDNQAIPRPQAVSFHLAQENDTLNGGQWL
LVDINMDKFDGRAERINITLPHRLLNRIDSLVQQHPGYGSRSAFLAAAARNELLKVG

Nucleotide

• Length: 414 bp

>AT183167 NZ_CP086726:c1822940-1822763 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA