Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4030245..4030900 Replicon chromosome
Accession NZ_CP065673
Organism Serratia plymuthica strain FDAARGOS_907

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B1KUT7
Locus tag I6G64_RS18885 Protein ID WP_006318241.1
Coordinates 4030511..4030900 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B1KUW5
Locus tag I6G64_RS18880 Protein ID WP_006318240.1
Coordinates 4030245..4030508 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G64_RS18865 4026581..4027480 - 900 WP_063197338.1 lipid kinase YegS -
I6G64_RS18870 4027969..4029321 - 1353 WP_004951966.1 tRNA 5-hydroxyuridine modification protein YegQ -
I6G64_RS18875 4029557..4029895 - 339 WP_004951963.1 YegP family protein -
I6G64_RS18880 4030245..4030508 + 264 WP_006318240.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6G64_RS18885 4030511..4030900 + 390 WP_006318241.1 type II toxin-antitoxin system VapC family toxin Toxin
I6G64_RS18890 4030895..4031611 - 717 WP_004951961.1 two-component system response regulator BaeR -
I6G64_RS18895 4031611..4032993 - 1383 WP_062868259.1 two-component system sensor histidine kinase BaeS -
I6G64_RS18900 4032990..4034423 - 1434 WP_063197336.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14048.36 Da        Isoelectric Point: 7.8817

>T183165 WP_006318241.1 NZ_CP065673:4030511-4030900 [Serratia plymuthica]
MYMFDTNTVSHLFRRHPGLLSAMEKVPPSTVCISSITEAELLFGVAKRQSKALKAMVTAFLAAVTVYDWDSEAARCYGVM
RASMEKKGKVLGALDQLIAAHALSRGATMVTSDRAFGMVSGLDVEDWTL

Download         Length: 390 bp

>T183165 NZ_CP086726:1749314-1749457 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10140.43 Da        Isoelectric Point: 4.8950

>AT183165 WP_006318240.1 NZ_CP065673:4030245-4030508 [Serratia plymuthica]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWEPLLNIIAKTPVPHDFLGADERQQGIADR
DPFAEEE

Download         Length: 264 bp

>AT183165 NZ_CP086726:c1749576-1749390 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KUT7

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1KUW5

References