Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4030245..4030900 Replicon chromosome
Accession NZ_CP065673
Organism Serratia plymuthica strain FDAARGOS_907

Toxin (Protein)


Gene name vapC Uniprot ID A0A1B1KUT7
Locus tag I6G64_RS18885 Protein ID WP_006318241.1
Coordinates 4030511..4030900 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1B1KUW5
Locus tag I6G64_RS18880 Protein ID WP_006318240.1
Coordinates 4030245..4030508 (+) Length 88 a.a.

Genomic Context

I6G64_RS18880I6G64_RS18885I6G64_RS18865I6G64_RS18870I6G64_RS18875I6G64_RS18890I6G64_RS18895I6G64_RS18900
Location: 4030245..4030508 (264 bp)
Type: Antitoxin
Protein ID: WP_006318240.1
Location: 4030511..4030900 (390 bp)
Type: Toxin
Protein ID: WP_006318241.1
Location: 4026581..4027480 (900 bp)
Type: Others
Protein ID: WP_063197338.1
Location: 4027969..4029321 (1353 bp)
Type: Others
Protein ID: WP_004951966.1
Location: 4029557..4029895 (339 bp)
Type: Others
Protein ID: WP_004951963.1
Location: 4030895..4031611 (717 bp)
Type: Others
Protein ID: WP_004951961.1
Location: 4031611..4032993 (1383 bp)
Type: Others
Protein ID: WP_062868259.1
Location: 4032990..4034423 (1434 bp)
Type: Others
Protein ID: WP_063197336.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6G64_RS188654026581..4027480-900WP_063197338.1lipid kinase YegS-
I6G64_RS188704027969..4029321-1353WP_004951966.1tRNA 5-hydroxyuridine modification protein YegQ-
I6G64_RS188754029557..4029895-339WP_004951963.1YegP family protein-
I6G64_RS188804030245..4030508+264WP_006318240.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
I6G64_RS188854030511..4030900+390WP_006318241.1type II toxin-antitoxin system VapC family toxinToxin
I6G64_RS188904030895..4031611-717WP_004951961.1two-component system response regulator BaeR-
I6G64_RS188954031611..4032993-1383WP_062868259.1two-component system sensor histidine kinase BaeS-
I6G64_RS189004032990..4034423-1434WP_063197336.1MFS transporter-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14048.36 Da        Isoelectric Point: 7.8817

>T183165 WP_006318241.1 NZ_CP065673:4030511-4030900 [Serratia plymuthica]
MYMFDTNTVSHLFRRHPGLLSAMEKVPPSTVCISSITEAELLFGVAKRQSKALKAMVTAFLAAVTVYDWDSEAARCYGVM
RASMEKKGKVLGALDQLIAAHALSRGATMVTSDRAFGMVSGLDVEDWTL

Download         Length: 390 bp

>T183165 NZ_CP086726:1749314-1749457 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10140.43 Da        Isoelectric Point: 4.8950

>AT183165 WP_006318240.1 NZ_CP065673:4030245-4030508 [Serratia plymuthica]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWEPLLNIIAKTPVPHDFLGADERQQGIADR
DPFAEEE

Download         Length: 264 bp

>AT183165 NZ_CP086726:c1749576-1749390 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1B1KUT7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1B1KUW5

References